{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["104(37)"],"submitter":["Hwang JS"],"pubmed_abstract":["Cell lineages of cnidarians including Hydra represent the fundamental cell types of metazoans and provides us a unique opportunity to study the evolutionary diversification of cell type in the animal kingdom. Hydra contains epithelial cells as well as a multipotent interstitial cell (I-cell) that gives rise to nematocytes, nerve cells, gland cells, and germ-line cells. We used cDNA microarrays to identify cell type-specific genes by comparing gene expression in normal Hydra with animals lacking the I-cell lineage, so-called epithelial Hydra. We then performed in situ hybridization to localize expression to specific cell types. Eighty-six genes were shown to be expressed in specific cell types of the I-cell lineage. An additional 29 genes were expressed in epithelial cells and were down-reg"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["14735-40"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1963347"],"repository":["biostudies-literature"],"pubmed_title":["The evolutionary emergence of cell type-specific genes inferred from the gene expression analysis of Hydra."],"pmcid":["PMC1963347"],"pubmed_authors":["Ohyanagi H","Osato N","Hayakawa S","Ikeo K","Gojobori T","Hwang JS","Fujisawa T","David CN","Nishimiya-Fujisawa C"],"additional_accession":[]},"is_claimable":false,"name":"The evolutionary emergence of cell type-specific genes inferred from the gene expression analysis of Hydra.","description":"Cell lineages of cnidarians including Hydra represent the fundamental cell types of metazoans and provides us a unique opportunity to study the evolutionary diversification of cell type in the animal kingdom. Hydra contains epithelial cells as well as a multipotent interstitial cell (I-cell) that gives rise to nematocytes, nerve cells, gland cells, and germ-line cells. We used cDNA microarrays to identify cell type-specific genes by comparing gene expression in normal Hydra with animals lacking the I-cell lineage, so-called epithelial Hydra. We then performed in situ hybridization to localize expression to specific cell types. Eighty-six genes were shown to be expressed in specific cell types of the I-cell lineage. An additional 29 genes were expressed in epithelial cells and were down-reg","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Sep","modification":"2026-05-01T05:30:06.724Z","creation":"2026-04-29T03:08:31.537Z"},"accession":"S-EPMC1963347","cross_references":{"pubmed":["17766437"],"doi":["10.1073/pnas.0703331104"]}}