{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["94(4)"],"submitter":["Mizuki N"],"pubmed_abstract":["A member of a novel family of the human major histocompatibility complex (MHC) class I genes termed MIC (MHC class I chain-related genes), MICA, has been recently identified near the HLA-B gene on the short arm of human chromosome 6. The predicted amino acid sequence of the MICA chain suggests that it folds similarly to typical class I chains and may have the capacity to bind peptides or other short ligands. Therefore, MICA is predicted to have a specialized function in antigen presentation or T cell recognition. During nucleotide sequence analyses of the MICA genomic clone, we found a triplet repeat microsatellite polymorphism of (GCT/AGC)n in the transmembrane (TM) region of the MICA gene. In 68 HLA homozygous B cell lines, 5 distinct alleles of this microsatellite sequence were detected"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["1298-303"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC19785"],"repository":["biostudies-literature"],"pubmed_title":["Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Behcet disease."],"pmcid":["PMC19785"],"pubmed_authors":["Ohno S","Goto K","Yamazaki M","Ota M","Ando H","Mizuki N","Watanabe K","Inoko H","Nakamura S","Kimura M","Katsuyama Y","Bahram S"],"additional_accession":[]},"is_claimable":false,"name":"Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Behcet disease.","description":"A member of a novel family of the human major histocompatibility complex (MHC) class I genes termed MIC (MHC class I chain-related genes), MICA, has been recently identified near the HLA-B gene on the short arm of human chromosome 6. The predicted amino acid sequence of the MICA chain suggests that it folds similarly to typical class I chains and may have the capacity to bind peptides or other short ligands. Therefore, MICA is predicted to have a specialized function in antigen presentation or T cell recognition. During nucleotide sequence analyses of the MICA genomic clone, we found a triplet repeat microsatellite polymorphism of (GCT/AGC)n in the transmembrane (TM) region of the MICA gene. In 68 HLA homozygous B cell lines, 5 distinct alleles of this microsatellite sequence were detected","dates":{"release":"1997-01-01T00:00:00Z","publication":"1997 Feb","modification":"2025-04-04T09:42:59.367Z","creation":"2019-03-26T23:45:22Z"},"accession":"S-EPMC19785","cross_references":{"pubmed":["9037047"],"doi":["10.1073/pnas.94.4.1298"]}}