biostudies-literatureFu ZQNCI NIH HHS3413-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC19850biostudies-literatureUnknown95(7)Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. The crystal structure of human recombinant MTCP-1 protein has been determined at 2.0 A resolution by using multiwavelength anomalous dispersion data from selenomethionine-enriched protein and refined to an R factor of 0.21. MTCP-1 folds into a compact eight-stranded beta barrel structure with a short helix between the fourth and fifth strands. The topology is unique. The structure of TCL-1 has been predicted by molecular modeling based on 40% amino acid sequence identity with MTCP-1. The identical residues are clustered inside the barrel and on the surface at oneProceedings of the National Academy of Sciences of the United States of AmericaCrystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies.PMC19850P01 CA076259Weber ITSong SPDu Bois GCFu ZQVirgilio LRothstein JLCroce CMKulikovskaya IHarrison RWfalseCrystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies.Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. The crystal structure of human recombinant MTCP-1 protein has been determined at 2.0 A resolution by using multiwavelength anomalous dispersion data from selenomethionine-enriched protein and refined to an R factor of 0.21. MTCP-1 folds into a compact eight-stranded beta barrel structure with a short helix between the fourth and fifth strands. The topology is unique. The structure of TCL-1 has been predicted by molecular modeling based on 40% amino acid sequence identity with MTCP-1. The identical residues are clustered inside the barrel and on the surface at one1998-01-01T00:00:00Z1998 Mar2025-04-04T09:43:06.555Z2019-03-26T22:29:06ZS-EPMC19850952038010.1073/pnas.95.7.3413