biostudies-literatureFellay JNIAID NIH HHSMedical Research Council944-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC1991296biostudies-literatureUnknown317(5840)Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combatiScience (New York, N.Y.)A whole-genome association study of major determinants for host control of HIV-1.PMC1991296U19 AI067854-03G0200585MC_U137884177U19 AI067854Ge DZhang KEasterbrook PWyniger JGoldstein DBFrancioli PCossarizza ALetvin NLFellay JHaynes BFCozzi-Lepri ACastagna ADe Luca AMartinez-Picado JDescombes PLedergerber BObel NSmith JPMiro JMAntonarakis SEShianna KVMallal SMcMichael AJTelenti AWeale MColombo SGumbs CfalseA whole-genome association study of major determinants for host control of HIV-1.Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combati2007-01-01T00:00:00Z2007 Aug2025-04-03T22:52:21.77Z2019-06-06T15:22:47ZS-EPMC19912961764116510.1126/science.1143767