{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(9)"],"submitter":["Mita R"],"pubmed_abstract":["Brain fatty acid-binding protein (B-FABP) is normally expressed in radial glial cells, where it plays a role in the establishment of the radial glial fiber network required for neuronal migration. B-FABP is also expressed in astrocytoma tumors and in some malignant glioma cell lines. To address the role of B-FABP in malignant glioma, we have studied the growth properties of clonal populations of malignant glioma cells modified for B-FABP expression. Here, we demonstrate that expression of B-FABP in B-FABP-negative malignant glioma cells is accompanied by the appearance of radial glial-like properties, such as increased migration and extended bipolar cell processes, as well as reduced transformation. Conversely, B-FABP depletion in B-FABP-positive malignant glioma cells results in decreased"],"journal":["Neoplasia (New York, N.Y.)"],"pagination":["734-44"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1993858"],"repository":["biostudies-literature"],"pubmed_title":["B-FABP-expressing radial glial cells: the malignant glioma cell of origin?"],"pmcid":["PMC1993858"],"pubmed_authors":["Godbout R","Mita R","Glubrecht DD","Sung R","Coles JE","Sun X"],"additional_accession":[]},"is_claimable":false,"name":"B-FABP-expressing radial glial cells: the malignant glioma cell of origin?","description":"Brain fatty acid-binding protein (B-FABP) is normally expressed in radial glial cells, where it plays a role in the establishment of the radial glial fiber network required for neuronal migration. B-FABP is also expressed in astrocytoma tumors and in some malignant glioma cell lines. To address the role of B-FABP in malignant glioma, we have studied the growth properties of clonal populations of malignant glioma cells modified for B-FABP expression. Here, we demonstrate that expression of B-FABP in B-FABP-negative malignant glioma cells is accompanied by the appearance of radial glial-like properties, such as increased migration and extended bipolar cell processes, as well as reduced transformation. Conversely, B-FABP depletion in B-FABP-positive malignant glioma cells results in decreased","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Sep","modification":"2025-04-21T23:40:06.257Z","creation":"2019-03-27T02:21:34Z"},"accession":"S-EPMC1993858","cross_references":{"pubmed":["17898869"],"doi":["10.1593/neo.07439"]}}