biostudies-literatureUnknown9(9)Mita RBrain fatty acid-binding protein (B-FABP) is normally expressed in radial glial cells, where it plays a role in the establishment of the radial glial fiber network required for neuronal migration. B-FABP is also expressed in astrocytoma tumors and in some malignant glioma cell lines. To address the role of B-FABP in malignant glioma, we have studied the growth properties of clonal populations of malignant glioma cells modified for B-FABP expression. Here, we demonstrate that expression of B-FABP in B-FABP-negative malignant glioma cells is accompanied by the appearance of radial glial-like properties, such as increased migration and extended bipolar cell processes, as well as reduced transformation. Conversely, B-FABP depletion in B-FABP-positive malignant glioma cells results in decreasedNeoplasia (New York, N.Y.)734-44https://www.ebi.ac.uk/biostudies/studies/S-EPMC1993858biostudies-literatureB-FABP-expressing radial glial cells: the malignant glioma cell of origin?PMC1993858Godbout RMita RGlubrecht DDSung RColes JESun XfalseB-FABP-expressing radial glial cells: the malignant glioma cell of origin?Brain fatty acid-binding protein (B-FABP) is normally expressed in radial glial cells, where it plays a role in the establishment of the radial glial fiber network required for neuronal migration. B-FABP is also expressed in astrocytoma tumors and in some malignant glioma cell lines. To address the role of B-FABP in malignant glioma, we have studied the growth properties of clonal populations of malignant glioma cells modified for B-FABP expression. Here, we demonstrate that expression of B-FABP in B-FABP-negative malignant glioma cells is accompanied by the appearance of radial glial-like properties, such as increased migration and extended bipolar cell processes, as well as reduced transformation. Conversely, B-FABP depletion in B-FABP-positive malignant glioma cells results in decreased2007-01-01T00:00:00Z2007 Sep2025-04-21T23:40:06.257Z2019-03-27T02:21:34ZS-EPMC19938581789886910.1593/neo.07439