{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Woodruff PG"],"funding":["NCRR NIH HHS","NHLBI NIH HHS","NCI NIH HHS"],"pagination":["15858-63"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2000427"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["104(40)"],"pubmed_abstract":["Airway inflammation and epithelial remodeling are two key features of asthma. IL-13 and other cytokines produced during T helper type 2 cell-driven allergic inflammation contribute to airway epithelial goblet cell metaplasia and may alter epithelial-mesenchymal signaling, leading to increased subepithelial fibrosis or hyperplasia of smooth muscle. The beneficial effects of corticosteroids in asthma could relate to their ability to directly or indirectly decrease epithelial cell activation by inflammatory cells and cytokines. To identify markers of epithelial cell dysfunction and the effects of corticosteroids on epithelial cells in asthma, we studied airway epithelial cells collected from asthmatic subjects enrolled in a randomized controlled trial of inhaled corticosteroids, from healthy "],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids."],"pmcid":["PMC2000427"],"funding_grant_id":["R01 HL072301","M01 RR000083","HL5683","CA020535","R01 HL080414","K23 RR017002","RR00083","HL66564","HL080414","P50 HL056385","RR17002","RR00079","R01 HL066564","HL72301","M01 RR000079","R01 HL085089","R01 CA020535","R37 CA020535"],"pubmed_authors":["Yang YH","Ellwanger A","Sidhu SS","Donnelly S","Woodruff PG","Fahy JV","Pantoja C","Erle DJ","Dao-Pick TP","Boushey HA","Barker CS","Yamamoto KR","Dolganov GM"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids.","description":"Airway inflammation and epithelial remodeling are two key features of asthma. IL-13 and other cytokines produced during T helper type 2 cell-driven allergic inflammation contribute to airway epithelial goblet cell metaplasia and may alter epithelial-mesenchymal signaling, leading to increased subepithelial fibrosis or hyperplasia of smooth muscle. The beneficial effects of corticosteroids in asthma could relate to their ability to directly or indirectly decrease epithelial cell activation by inflammatory cells and cytokines. To identify markers of epithelial cell dysfunction and the effects of corticosteroids on epithelial cells in asthma, we studied airway epithelial cells collected from asthmatic subjects enrolled in a randomized controlled trial of inhaled corticosteroids, from healthy ","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Oct","modification":"2026-05-02T09:23:18.57Z","creation":"2019-03-27T02:21:38Z"},"accession":"S-EPMC2000427","cross_references":{"pubmed":["17898169"],"doi":["10.1073/pnas.0707413104"]}}