biostudies-literatureHeikkinen SNIDDK NIH HHS999-1013https://www.ebi.ac.uk/biostudies/studies/S-EPMC2020525biostudies-literatureUnknown1771(8)The peroxisome proliferator activated receptor gamma (PPARgamma) is a member in the nuclear receptor superfamily which mediates part of the regulatory effects of dietary fatty acids on gene expression. As PPARgamma also coordinates adipocyte differentiation, it is an important component in storing the excess nutritional energy as fat. Our genes have evolved into maximizing energy storage, and PPARgamma has a central role in the mismatch between our genes and our affluent western society which results in a broad range of metabolic disturbances, collectively known as the metabolic syndrome. A flurry of human and mouse studies has shed new light on the mechanisms how the commonly used insulin sensitizer drugs and PPARgamma activators, thiazolidinediones, act, and which of their physiological Biochimica et biophysica actaPPARgamma in human and mouse physiology.PMC2020525DK 67320R01 DK067320R01 DK067320-02R01 DK067320-01A1R01 DK067320-03Argmann CAAuwerx JHeikkinen SfalsePPARgamma in human and mouse physiology.The peroxisome proliferator activated receptor gamma (PPARgamma) is a member in the nuclear receptor superfamily which mediates part of the regulatory effects of dietary fatty acids on gene expression. As PPARgamma also coordinates adipocyte differentiation, it is an important component in storing the excess nutritional energy as fat. Our genes have evolved into maximizing energy storage, and PPARgamma has a central role in the mismatch between our genes and our affluent western society which results in a broad range of metabolic disturbances, collectively known as the metabolic syndrome. A flurry of human and mouse studies has shed new light on the mechanisms how the commonly used insulin sensitizer drugs and PPARgamma activators, thiazolidinediones, act, and which of their physiological 2007-01-01T00:00:00Z2007 Aug2025-04-21T22:44:14.41Z2019-06-06T15:23:20ZS-EPMC20205251747554610.1016/j.bbalip.2007.03.006