{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":54,"searchCount":0},"additional":{"submitter":["Pegg AE"],"funding":["NCI NIH HHS"],"pagination":["1071-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2030992"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(8)"],"pubmed_abstract":["This article summarizes the current understanding of known variant forms of the MGMT gene that encode an altered protein. Epidemiological studies have been carried out to test whether these alterations are associated with altered cancer risk. Laboratory studies using recombinant proteins and cells expressing the known variants have investigated the possible effects of these sequence alterations on the ability of the encoded O(6)-alkylguanine-DNA alkyltransferase protein to protect cells from alkylation damage and to respond to therapeutic inactivators currently undergoing trials for cancer chemotherapy."],"journal":["DNA repair"],"pubmed_title":["Human variants of O6-alkylguanine-DNA alkyltransferase."],"pmcid":["PMC2030992"],"funding_grant_id":["R37 CA018137","CA018137","R01 CA071976","CA071976","R01 CA018137","R01 CA071976-12","R01 CA018137-31"],"pubmed_authors":["Loktionova NA","Fang Q","Pegg AE"],"view_count":["54"],"additional_accession":[]},"is_claimable":false,"name":"Human variants of O6-alkylguanine-DNA alkyltransferase.","description":"This article summarizes the current understanding of known variant forms of the MGMT gene that encode an altered protein. Epidemiological studies have been carried out to test whether these alterations are associated with altered cancer risk. Laboratory studies using recombinant proteins and cells expressing the known variants have investigated the possible effects of these sequence alterations on the ability of the encoded O(6)-alkylguanine-DNA alkyltransferase protein to protect cells from alkylation damage and to respond to therapeutic inactivators currently undergoing trials for cancer chemotherapy.","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Aug","modification":"2024-11-12T00:22:17.222Z","creation":"2020-11-07T09:50:18Z"},"accession":"S-EPMC2030992","cross_references":{"pubmed":["17482892"],"doi":["10.1016/j.dnarep.2007.03.012"]}}