{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["95(10)"],"submitter":["Popovici C"],"pubmed_abstract":["Chromosome 8p11-12 is the site of a recurrent breakpoint in a myeloproliferative disorder that involves lymphoid (T- or B-cell), myeloid hyperplasia and eosinophilia, and evolves toward acute leukemia. This multilineage involvement suggests the malignant transformation of a primitive hematopoietic stem cell. In this disorder, the 8p11-12 region is associated with three different partners 6q27, 9q33, and 13q12. We describe here the molecular characterization of the t(8;13) translocation that involves the FGFR1 gene from 8p12, encoding a tyrosine kinase receptor for members of the fibroblast growth factor family, and a gene from 13q12, tentatively named FIM (Fused In Myeloproliferative disorders). FIM is related to DXS6673E, a candidate gene for X-linked mental retardation in Xq13.1; this de"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["5712-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC20444"],"repository":["biostudies-literature"],"pubmed_title":["Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)."],"pmcid":["PMC20444"],"pubmed_authors":["Popovici C","Birnbaum D","Chaffanet M","Jacrot M","Leroux D","Adelaide J","Guasch G","Pebusque MJ","Ollendorff V"],"additional_accession":[]},"is_claimable":false,"name":"Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13).","description":"Chromosome 8p11-12 is the site of a recurrent breakpoint in a myeloproliferative disorder that involves lymphoid (T- or B-cell), myeloid hyperplasia and eosinophilia, and evolves toward acute leukemia. This multilineage involvement suggests the malignant transformation of a primitive hematopoietic stem cell. In this disorder, the 8p11-12 region is associated with three different partners 6q27, 9q33, and 13q12. We describe here the molecular characterization of the t(8;13) translocation that involves the FGFR1 gene from 8p12, encoding a tyrosine kinase receptor for members of the fibroblast growth factor family, and a gene from 13q12, tentatively named FIM (Fused In Myeloproliferative disorders). FIM is related to DXS6673E, a candidate gene for X-linked mental retardation in Xq13.1; this de","dates":{"release":"1998-01-01T00:00:00Z","publication":"1998 May","modification":"2025-04-04T09:42:58.014Z","creation":"2019-03-27T00:17:47Z"},"accession":"S-EPMC20444","cross_references":{"pubmed":["9576949"],"doi":["10.1073/pnas.95.10.5712"]}}