biostudies-literatureUnknown95(10)Popovici CChromosome 8p11-12 is the site of a recurrent breakpoint in a myeloproliferative disorder that involves lymphoid (T- or B-cell), myeloid hyperplasia and eosinophilia, and evolves toward acute leukemia. This multilineage involvement suggests the malignant transformation of a primitive hematopoietic stem cell. In this disorder, the 8p11-12 region is associated with three different partners 6q27, 9q33, and 13q12. We describe here the molecular characterization of the t(8;13) translocation that involves the FGFR1 gene from 8p12, encoding a tyrosine kinase receptor for members of the fibroblast growth factor family, and a gene from 13q12, tentatively named FIM (Fused In Myeloproliferative disorders). FIM is related to DXS6673E, a candidate gene for X-linked mental retardation in Xq13.1; this deProceedings of the National Academy of Sciences of the United States of America5712-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC20444biostudies-literatureFibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13).PMC20444Popovici CBirnbaum DChaffanet MJacrot MLeroux DAdelaide JGuasch GPebusque MJOllendorff VfalseFibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13).Chromosome 8p11-12 is the site of a recurrent breakpoint in a myeloproliferative disorder that involves lymphoid (T- or B-cell), myeloid hyperplasia and eosinophilia, and evolves toward acute leukemia. This multilineage involvement suggests the malignant transformation of a primitive hematopoietic stem cell. In this disorder, the 8p11-12 region is associated with three different partners 6q27, 9q33, and 13q12. We describe here the molecular characterization of the t(8;13) translocation that involves the FGFR1 gene from 8p12, encoding a tyrosine kinase receptor for members of the fibroblast growth factor family, and a gene from 13q12, tentatively named FIM (Fused In Myeloproliferative disorders). FIM is related to DXS6673E, a candidate gene for X-linked mental retardation in Xq13.1; this de1998-01-01T00:00:00Z1998 May2025-04-04T09:42:58.014Z2019-03-27T00:17:47ZS-EPMC20444957694910.1073/pnas.95.10.5712