{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tokuo H"],"funding":["NIDCD NIH HHS","NIAMS NIH HHS"],"pagination":["229-38"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2064759"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["179(2)"],"pubmed_abstract":["Filopodia are actin-rich fingerlike protrusions found at the leading edge of migrating cells and are believed to play a role in directional sensing. Previous studies have shown that myosin-X (myoX) promotes filopodia formation and that this is mediated through its ability to deliver specific cargoes to the cell periphery (Tokuo, H., and M. Ikebe. 2004. Biochem Biophys. Commun. 319:214-220; Zhang, H., J.S. Berg, Z. Li, Y. Wang, P. Lang, A.D. Sousa, A. Bhaskar, R.E. Cheney, and S. Stromblad. 2004. Nat. Cell Biol. 6:523-531; Bohil, A.B., B.W. Robertson, and R.E. Cheney. 2006. Proc. Natl. Acad. Sci. USA. 103:12411-12416; Zhu, X.J., C.Z. Wang, P.G. Dai, Y. Xie, N.N. Song, Y. Liu, Q.S. Du, L. Mei, Y.Q. Ding, and W.C. Xiong. 2007. Nat. Cell Biol. 9:184-192). In this study, we show that the motor "],"journal":["The Journal of cell biology"],"pubmed_title":["The motor activity of myosin-X promotes actin fiber convergence at the cell periphery to initiate filopodia formation."],"pmcid":["PMC2064759"],"funding_grant_id":["R01 AR048898","R01 AR048526","R01 DC006103","DC006103","AR048526","AR048898"],"pubmed_authors":["Tokuo H","Ikebe M","Mabuchi K"],"additional_accession":[]},"is_claimable":false,"name":"The motor activity of myosin-X promotes actin fiber convergence at the cell periphery to initiate filopodia formation.","description":"Filopodia are actin-rich fingerlike protrusions found at the leading edge of migrating cells and are believed to play a role in directional sensing. Previous studies have shown that myosin-X (myoX) promotes filopodia formation and that this is mediated through its ability to deliver specific cargoes to the cell periphery (Tokuo, H., and M. Ikebe. 2004. Biochem Biophys. Commun. 319:214-220; Zhang, H., J.S. Berg, Z. Li, Y. Wang, P. Lang, A.D. Sousa, A. Bhaskar, R.E. Cheney, and S. Stromblad. 2004. Nat. Cell Biol. 6:523-531; Bohil, A.B., B.W. Robertson, and R.E. Cheney. 2006. Proc. Natl. Acad. Sci. USA. 103:12411-12416; Zhu, X.J., C.Z. Wang, P.G. Dai, Y. Xie, N.N. Song, Y. Liu, Q.S. Du, L. Mei, Y.Q. Ding, and W.C. Xiong. 2007. Nat. Cell Biol. 9:184-192). In this study, we show that the motor ","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Oct","modification":"2026-05-05T04:30:10.922Z","creation":"2019-03-26T23:03:03Z"},"accession":"S-EPMC2064759","cross_references":{"pubmed":["17954606"],"doi":["10.1083/jcb.200703178"]}}