{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Chalmel F"],"pubmed_abstract":["<h4>Background</h4>Cone degeneration is the hallmark of the inherited retinal disease retinitis pigmentosa. We have previously identified a trophic factor \"Rod-derived Cone Viability Factor (RdCVF) that is secreted by rods and promote cone viability in a mouse model of the disease.<h4>Results</h4>Here we report the bioinformatic identification and the experimental analysis of RdCVF2, a second trophic factor belonging to the Rod-derived Cone Viability Factor family. The mouse RdCVF gene is known to be bifunctional, encoding both a long thioredoxin-like isoform (RdCVF-L) and a short isoform with trophic cone photoreceptor viability activity (RdCVF-S). RdCVF2 shares many similarities with RdCVF in terms of gene structure, expression in a rod-dependent manner and protein 3D structure. Furtherm"],"journal":["BMC molecular biology"],"pagination":["74"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2064930"],"repository":["biostudies-literature"],"pubmed_title":["Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential."],"pmcid":["PMC2064930"],"pubmed_authors":["Chalmel F","Sahel JA","Berdugo N","Leveillard T","Morel E","Lardenois A","Jaillard C","Koehl P","Lambrou G","Poch O","Holmgren A"],"additional_accession":[]},"is_claimable":false,"name":"Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential.","description":"<h4>Background</h4>Cone degeneration is the hallmark of the inherited retinal disease retinitis pigmentosa. We have previously identified a trophic factor \"Rod-derived Cone Viability Factor (RdCVF) that is secreted by rods and promote cone viability in a mouse model of the disease.<h4>Results</h4>Here we report the bioinformatic identification and the experimental analysis of RdCVF2, a second trophic factor belonging to the Rod-derived Cone Viability Factor family. The mouse RdCVF gene is known to be bifunctional, encoding both a long thioredoxin-like isoform (RdCVF-L) and a short isoform with trophic cone photoreceptor viability activity (RdCVF-S). RdCVF2 shares many similarities with RdCVF in terms of gene structure, expression in a rod-dependent manner and protein 3D structure. Furtherm","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Aug","modification":"2026-05-05T04:30:26.92Z","creation":"2026-04-07T21:21:45.109Z"},"accession":"S-EPMC2064930","cross_references":{"pubmed":["17764561"],"doi":["10.1186/1471-2199-8-74"]}}