biostudies-literatureLi YNIGMS NIH HHS1391-1397https://www.ebi.ac.uk/biostudies/studies/S-EPMC2084221biostudies-literatureUnknown18(12)The ability of commercially available amino acid derivatives, especially Fmoc-Trp(Boc)-OH, to differentiate enantiomers of chiral phosphonates, phosphinates, phosphates, phosphine oxides, and phosphonamidates is demonstrated with (31)P, (13)C, and (1)H NMR spectroscopy. The chiral differentiation provided a rapid and convenient method for measuring the enantiomeric purity of these phosphorus compounds.Tetrahedron, asymmetryDifferentiation of chiral phosphorus enantiomers by P and H NMR spectroscopy using amino acid derivatives as chemical solvating agents.PMC2084221R01 GM068550R01 GM068550-04Li YRaushel FMfalseDifferentiation of chiral phosphorus enantiomers by P and H NMR spectroscopy using amino acid derivatives as chemical solvating agents.The ability of commercially available amino acid derivatives, especially Fmoc-Trp(Boc)-OH, to differentiate enantiomers of chiral phosphonates, phosphinates, phosphates, phosphine oxides, and phosphonamidates is demonstrated with (31)P, (13)C, and (1)H NMR spectroscopy. The chiral differentiation provided a rapid and convenient method for measuring the enantiomeric purity of these phosphorus compounds.2007-01-01T00:00:00Z2007 Jul2025-04-04T14:48:19.51Z2019-03-27T02:21:59ZS-EPMC20842211803798310.1016/j.tetasy.2007.06.012