{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chauhan AK"],"funding":["NHLBI NIH HHS"],"pagination":["767-76"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2118248"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["203(3)"],"pubmed_abstract":["The metalloprotease ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type I repeats 13) cleaves highly adhesive large von Willebrand factor (VWF) multimers after their release from the endothelium. ADAMTS13 deficiency is linked to a life-threatening disorder, thrombotic thrombocytopenic purpura (TTP), characterized by platelet-rich thrombi in the microvasculature. Here, we show spontaneous thrombus formation in activated microvenules of Adamts13-/- mice by intravital microscopy. Strikingly, we found that ADAMTS13 down-regulates both platelet adhesion to exposed subendothelium and thrombus formation in injured arterioles. An inhibitory antibody to ADAMTS13 infused in wild-type mice prolonged adhesion of platelets to endothelium and induced thrombi formation with emboliza"],"journal":["The Journal of experimental medicine"],"pubmed_title":["Systemic antithrombotic effects of ADAMTS13."],"pmcid":["PMC2118248"],"funding_grant_id":["R37 HL041002","R37 HL41002","R01 HL39693","R01 HL041002","P01 HL057346","R01 HL039693"],"pubmed_authors":["Motto DG","Plaimauer B","Bergmeier W","Lamb CB","Scheiflinger F","Chauhan AK","Wagner DD","Ginsburg D","Dockal M"],"additional_accession":[]},"is_claimable":false,"name":"Systemic antithrombotic effects of ADAMTS13.","description":"The metalloprotease ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type I repeats 13) cleaves highly adhesive large von Willebrand factor (VWF) multimers after their release from the endothelium. ADAMTS13 deficiency is linked to a life-threatening disorder, thrombotic thrombocytopenic purpura (TTP), characterized by platelet-rich thrombi in the microvasculature. Here, we show spontaneous thrombus formation in activated microvenules of Adamts13-/- mice by intravital microscopy. Strikingly, we found that ADAMTS13 down-regulates both platelet adhesion to exposed subendothelium and thrombus formation in injured arterioles. An inhibitory antibody to ADAMTS13 infused in wild-type mice prolonged adhesion of platelets to endothelium and induced thrombi formation with emboliza","dates":{"release":"2006-01-01T00:00:00Z","publication":"2006 Mar","modification":"2026-04-16T05:13:21.045Z","creation":"2019-03-26T23:29:37Z"},"accession":"S-EPMC2118248","cross_references":{"pubmed":["16533881"],"doi":["10.1084/jem.20051732"]}}