biostudies-literatureLai AYNIAID NIH HHSNCI NIH HHS1867-73https://www.ebi.ac.uk/biostudies/studies/S-EPMC2118384biostudies-literatureUnknown203(8)The mechanism of lineage commitment from hematopoietic stem cells (HSCs) is not well understood. Although commitment to either the lymphoid or the myeloid lineage is popularly viewed as the first step of lineage restriction from HSCs, this model of hematopoietic differentiation has recently been challenged. The previous identification of multipotent progenitors (MPPs) that can produce lymphocytes and granulocyte/macrophages (GMs) but lacks erythroid differentiation ability suggests the existence of an alternative HSC differentiation program. Contribution to different hematopoietic lineages by these MPPs under physiological conditions, however, has not been carefully examined. In this study, we performed a refined characterization of MPPs by subfractionating three distinct subsets based on The Journal of experimental medicineAsymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors.PMC2118384AI52077R01 AI056123T32 AI052077AI056123R01 CA098129CA098129Lai AYKondo MfalseAsymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors.The mechanism of lineage commitment from hematopoietic stem cells (HSCs) is not well understood. Although commitment to either the lymphoid or the myeloid lineage is popularly viewed as the first step of lineage restriction from HSCs, this model of hematopoietic differentiation has recently been challenged. The previous identification of multipotent progenitors (MPPs) that can produce lymphocytes and granulocyte/macrophages (GMs) but lacks erythroid differentiation ability suggests the existence of an alternative HSC differentiation program. Contribution to different hematopoietic lineages by these MPPs under physiological conditions, however, has not been carefully examined. In this study, we performed a refined characterization of MPPs by subfractionating three distinct subsets based on 2006-01-01T00:00:00Z2006 Aug2026-03-16T16:40:57.006Z2019-03-26T23:28:23ZS-EPMC21183841688026110.1084/jem.20060697