{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(1)"],"submitter":["Anantharaman V"],"pubmed_abstract":["<h4>Background</h4>A great diversity of multi-pass membrane receptors, typically with 7 transmembrane (TM) helices, is observed in the eukaryote crown group. So far, they are relatively rare in the prokaryotes, and are restricted to the well-characterized sensory rhodopsins of various phototropic prokaryotes.<h4>Results</h4>Utilizing the currently available wealth of prokaryotic genomic sequences, we set up a computational screen to identify putative 7 (TM) and other multi-pass membrane receptors in prokaryotes. As a result of this procedure we were able to recover two widespread families of 7 TM receptors in bacteria that are distantly related to the eukaryotic 7 TM receptors and prokaryotic rhodopsins. Using sequence profile analysis, we were able to establish that the first members of t"],"journal":["BMC genomics"],"pagination":["34"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC212514"],"repository":["biostudies-literature"],"pubmed_title":["Application of comparative genomics in the identification and analysis of novel families of membrane-associated receptors in bacteria."],"pmcid":["PMC212514"],"pubmed_authors":["Anantharaman V","Aravind L"],"additional_accession":[]},"is_claimable":false,"name":"Application of comparative genomics in the identification and analysis of novel families of membrane-associated receptors in bacteria.","description":"<h4>Background</h4>A great diversity of multi-pass membrane receptors, typically with 7 transmembrane (TM) helices, is observed in the eukaryote crown group. So far, they are relatively rare in the prokaryotes, and are restricted to the well-characterized sensory rhodopsins of various phototropic prokaryotes.<h4>Results</h4>Utilizing the currently available wealth of prokaryotic genomic sequences, we set up a computational screen to identify putative 7 (TM) and other multi-pass membrane receptors in prokaryotes. As a result of this procedure we were able to recover two widespread families of 7 TM receptors in bacteria that are distantly related to the eukaryotic 7 TM receptors and prokaryotic rhodopsins. Using sequence profile analysis, we were able to establish that the first members of t","dates":{"release":"2003-01-01T00:00:00Z","publication":"2003 Aug","modification":"2025-04-21T20:50:21.285Z","creation":"2019-03-27T00:35:48Z"},"accession":"S-EPMC212514","cross_references":{"pubmed":["12914674"],"doi":["10.1186/1471-2164-4-34"]}}