{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["tom Dieck S"],"funding":["NICHD NIH HHS"],"pagination":["499-509"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2133055"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["142(2)"],"pubmed_abstract":["The molecular architecture of the cytomatrix of presynaptic nerve terminals is poorly understood. Here we show that Bassoon, a novel protein of >400,000 Mr, is a new component of the presynaptic cytoskeleton. The murine bassoon gene maps to chromosome 9F. A comparison with the corresponding rat cDNA identified 10 exons within its protein-coding region. The Bassoon protein is predicted to contain two double-zinc fingers, several coiled-coil domains, and a stretch of polyglutamines (24 and 11 residues in rat and mouse, respectively). In some human proteins, e.g., Huntingtin, abnormal amplification of such poly-glutamine regions causes late-onset neurodegeneration. Bassoon is highly enriched in synaptic protein preparations. In cultured hippocampal neurons, Bassoon colocalizes with the synapt"],"journal":["The Journal of cell biology"],"pubmed_title":["Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals."],"pmcid":["PMC2133055"],"funding_grant_id":["P50 HD32901"],"pubmed_authors":["Kindler S","Sanmarti-Vila L","Richter K","Wex H","Kampf U","Soyke A","Langnaese K","Smalla KH","Garner CC","Gundelfinger ED","tom Dieck S","Stumm M","Franzer JT"],"additional_accession":[]},"is_claimable":false,"name":"Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals.","description":"The molecular architecture of the cytomatrix of presynaptic nerve terminals is poorly understood. Here we show that Bassoon, a novel protein of >400,000 Mr, is a new component of the presynaptic cytoskeleton. The murine bassoon gene maps to chromosome 9F. A comparison with the corresponding rat cDNA identified 10 exons within its protein-coding region. The Bassoon protein is predicted to contain two double-zinc fingers, several coiled-coil domains, and a stretch of polyglutamines (24 and 11 residues in rat and mouse, respectively). In some human proteins, e.g., Huntingtin, abnormal amplification of such poly-glutamine regions causes late-onset neurodegeneration. Bassoon is highly enriched in synaptic protein preparations. In cultured hippocampal neurons, Bassoon colocalizes with the synapt","dates":{"release":"1998-01-01T00:00:00Z","publication":"1998 Jul","modification":"2025-04-05T08:52:26.406Z","creation":"2019-03-26T23:02:30Z"},"accession":"S-EPMC2133055","cross_references":{"pubmed":["9679147"],"doi":["10.1083/jcb.142.2.499"]}}