{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["143(5)"],"submitter":["Gregory SL"],"pubmed_abstract":["Mutations in kakapo were recovered in genetic screens designed to isolate genes required for integrin-mediated adhesion in Drosophila. We cloned the gene and found that it encodes a large protein (>5,000 amino acids) that is highly similar to plectin and BPAG1 over the first 1,000-amino acid region, and contains within this region an alpha-actinin type actin-binding domain. A central region containing dystrophin-like repeats is followed by a carboxy domain that is distinct from plectin and dystrophin, having neither the intermediate filament-binding domain of plectin nor the dystroglycan/syntrophin-binding domain of dystrophin. Instead, Kakapo has a carboxy terminus similar to the growth arrest-specific protein Gas2. Kakapo is strongly expressed late during embryogenesis at the most promin"],"journal":["The Journal of cell biology"],"pagination":["1271-82"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2133084"],"repository":["biostudies-literature"],"pubmed_title":["kakapo, a gene required for adhesion between and within cell layers in Drosophila, encodes a large cytoskeletal linker protein related to plectin and dystrophin."],"pmcid":["PMC2133084"],"pubmed_authors":["Gregory SL","Brown NH"],"additional_accession":[]},"is_claimable":false,"name":"kakapo, a gene required for adhesion between and within cell layers in Drosophila, encodes a large cytoskeletal linker protein related to plectin and dystrophin.","description":"Mutations in kakapo were recovered in genetic screens designed to isolate genes required for integrin-mediated adhesion in Drosophila. We cloned the gene and found that it encodes a large protein (>5,000 amino acids) that is highly similar to plectin and BPAG1 over the first 1,000-amino acid region, and contains within this region an alpha-actinin type actin-binding domain. A central region containing dystrophin-like repeats is followed by a carboxy domain that is distinct from plectin and dystrophin, having neither the intermediate filament-binding domain of plectin nor the dystroglycan/syntrophin-binding domain of dystrophin. Instead, Kakapo has a carboxy terminus similar to the growth arrest-specific protein Gas2. Kakapo is strongly expressed late during embryogenesis at the most promin","dates":{"release":"1998-01-01T00:00:00Z","publication":"1998 Nov","modification":"2025-04-05T08:52:34.015Z","creation":"2019-03-26T23:02:30Z"},"accession":"S-EPMC2133084","cross_references":{"pubmed":["9832555"],"doi":["10.1083/jcb.143.5.1271"]}}