{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(24)"],"submitter":["Kim WJ"],"pubmed_abstract":["The signaling lipid molecule 15-deoxy-delta 12,14-prostaglandin J2 (15d-PGJ2) has multiple cellular functions, including anti-inflammatory and antineoplastic activities. Here, we report that 15d-PGJ2 blocks translation through inactivation of translational initiation factor eIF4A. Binding of 15d-PGJ2 to eIF4A blocks the interaction between eIF4A and eIF4G that is essential for translation of many mRNAs. Cysteine 264 in eIF4A is the target site of 15d-PGJ2. The antineoplastic activity of 15d-PGJ2 is likely attributed to inhibition of translation. Moreover, inhibition of translation by 15d-PGJ2 results in stress granule (SG) formation, into which TRAF2 is sequestered. The sequestration of TRAF2 contributes to the anti-inflammatory activity of 15d-PGJ2. These findings reveal a novel cross-tal"],"journal":["The EMBO journal"],"pagination":["5020-32"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2140107"],"repository":["biostudies-literature"],"pubmed_title":["Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A."],"pmcid":["PMC2140107"],"pubmed_authors":["Kim WJ","Jang SK","Kim JH"],"additional_accession":[]},"is_claimable":false,"name":"Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A.","description":"The signaling lipid molecule 15-deoxy-delta 12,14-prostaglandin J2 (15d-PGJ2) has multiple cellular functions, including anti-inflammatory and antineoplastic activities. Here, we report that 15d-PGJ2 blocks translation through inactivation of translational initiation factor eIF4A. Binding of 15d-PGJ2 to eIF4A blocks the interaction between eIF4A and eIF4G that is essential for translation of many mRNAs. Cysteine 264 in eIF4A is the target site of 15d-PGJ2. The antineoplastic activity of 15d-PGJ2 is likely attributed to inhibition of translation. Moreover, inhibition of translation by 15d-PGJ2 results in stress granule (SG) formation, into which TRAF2 is sequestered. The sequestration of TRAF2 contributes to the anti-inflammatory activity of 15d-PGJ2. These findings reveal a novel cross-tal","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Dec","modification":"2025-04-18T19:31:29.849Z","creation":"2019-03-27T02:22:09Z"},"accession":"S-EPMC2140107","cross_references":{"pubmed":["18034160"],"doi":["10.1038/sj.emboj.7601920"]}}