{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(20)"],"submitter":["Barbier J"],"pubmed_abstract":["When cells are exposed to a genotoxic stress, a DNA surveillance pathway that involves p53 is activated, allowing DNA repair. Eukaryotic cells have also evolved a mechanism called mRNA surveillance that controls the quality of mRNAs. Indeed, mutant mRNAs carrying premature translation termination codons (PTCs) are selectively degraded by the nonsense-mediated mRNA decay (NMD) pathway. However, in the case of particular genes, such as proto-oncogenes, mutations that do not create PTCs and therefore that do not induce mRNA degradation, can be harmful to cells. In this study, we showed that the H-ras gene in the absence of mutations produces an NMD-target splice variant that is degraded in the cytosol. We observed that a treatment with the genotoxic stress inducer camptothecin for 6 h favored"],"journal":["Molecular and cellular biology"],"pagination":["7315-33"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2168895"],"repository":["biostudies-literature"],"pubmed_title":["Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways."],"pmcid":["PMC2168895"],"pubmed_authors":["Dutertre M","Auboeuf D","de la Grange P","Bittencourt D","Sanchez G","Gratadou L","Barbier J"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways.","description":"When cells are exposed to a genotoxic stress, a DNA surveillance pathway that involves p53 is activated, allowing DNA repair. Eukaryotic cells have also evolved a mechanism called mRNA surveillance that controls the quality of mRNAs. Indeed, mutant mRNAs carrying premature translation termination codons (PTCs) are selectively degraded by the nonsense-mediated mRNA decay (NMD) pathway. However, in the case of particular genes, such as proto-oncogenes, mutations that do not create PTCs and therefore that do not induce mRNA degradation, can be harmful to cells. In this study, we showed that the H-ras gene in the absence of mutations produces an NMD-target splice variant that is degraded in the cytosol. We observed that a treatment with the genotoxic stress inducer camptothecin for 6 h favored","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Oct","modification":"2025-04-21T14:52:05.082Z","creation":"2019-03-27T02:22:21Z"},"accession":"S-EPMC2168895","cross_references":{"pubmed":["17709397"],"doi":["10.1128/mcb.00272-07","10.1128/MCB.00272-07"]}}