{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(20)"],"submitter":["Tan NS"],"pubmed_abstract":["After an injury, keratinocytes acquire the plasticity necessary for the reepithelialization of the wound. Here, we identify a novel pathway by which a nuclear hormone receptor, until now better known for its metabolic functions, potentiates cell migration. We show that peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) enhances two phosphatidylinositol 3-kinase-dependent pathways, namely, the Akt and the Rho-GTPase pathways. This PPARbeta/delta activity amplifies the response of keratinocytes to a chemotactic signal, promotes integrin recycling and remodeling of the actin cytoskeleton, and thereby favors cell migration. Using three-dimensional wound reconstructions, we demonstrate that these defects have a strong impact on in vivo skin healing, since PPARbeta/delta-/- m"],"journal":["Molecular and cellular biology"],"pagination":["7161-75"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2168901"],"repository":["biostudies-literature"],"pubmed_title":["The nuclear hormone receptor peroxisome proliferator-activated receptor beta/delta potentiates cell chemotactism, polarization, and migration."],"pmcid":["PMC2168901"],"pubmed_authors":["Montagner A","Wahli W","Tan NS","Michalik L","Bordier-ten-Heggeler B","Icre G"],"additional_accession":[]},"is_claimable":false,"name":"The nuclear hormone receptor peroxisome proliferator-activated receptor beta/delta potentiates cell chemotactism, polarization, and migration.","description":"After an injury, keratinocytes acquire the plasticity necessary for the reepithelialization of the wound. Here, we identify a novel pathway by which a nuclear hormone receptor, until now better known for its metabolic functions, potentiates cell migration. We show that peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) enhances two phosphatidylinositol 3-kinase-dependent pathways, namely, the Akt and the Rho-GTPase pathways. This PPARbeta/delta activity amplifies the response of keratinocytes to a chemotactic signal, promotes integrin recycling and remodeling of the actin cytoskeleton, and thereby favors cell migration. Using three-dimensional wound reconstructions, we demonstrate that these defects have a strong impact on in vivo skin healing, since PPARbeta/delta-/- m","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Oct","modification":"2025-04-21T14:52:11.914Z","creation":"2019-03-27T02:22:22Z"},"accession":"S-EPMC2168901","cross_references":{"pubmed":["17682064"],"doi":["10.1128/MCB.00436-07","10.1128/mcb.00436-07"]}}