{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schwabish MA"],"funding":["NIGMS NIH HHS"],"pagination":["6987-95"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2168902"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(20)"],"pubmed_abstract":["The Swi/Snf nucleosome-remodeling complex is recruited by DNA-binding activator proteins, whereupon it alters chromatin structure to increase preinitiation complex formation and transcription. At the SUC2 promoter, the Swi/Snf complex is required for histone eviction in a manner that is independent of transcriptional activity. Swi/Snf travels through coding regions with elongating RNA polymerase (Pol) II, and swi2 mutants exhibit sensitivity to drugs affecting Pol elongation. In FACT-depleted cells, Swi/Snf is important for internal initiation within coding regions, suggesting that Swi/Snf is important for histone eviction that occurs during Pol II elongation. Taken together, these observations suggest that Swi/Snf is important for histone eviction at enhancers and that it also functions as a Pol II elongation factor."],"journal":["Molecular and cellular biology"],"pubmed_title":["The Swi/Snf complex is important for histone eviction during transcriptional activation and RNA polymerase II elongation in vivo."],"pmcid":["PMC2168902"],"funding_grant_id":["R01 GM030186","GM30186","R37 GM030186"],"pubmed_authors":["Schwabish MA","Struhl K"],"additional_accession":[]},"is_claimable":false,"name":"The Swi/Snf complex is important for histone eviction during transcriptional activation and RNA polymerase II elongation in vivo.","description":"The Swi/Snf nucleosome-remodeling complex is recruited by DNA-binding activator proteins, whereupon it alters chromatin structure to increase preinitiation complex formation and transcription. At the SUC2 promoter, the Swi/Snf complex is required for histone eviction in a manner that is independent of transcriptional activity. Swi/Snf travels through coding regions with elongating RNA polymerase (Pol) II, and swi2 mutants exhibit sensitivity to drugs affecting Pol elongation. In FACT-depleted cells, Swi/Snf is important for internal initiation within coding regions, suggesting that Swi/Snf is important for histone eviction that occurs during Pol II elongation. Taken together, these observations suggest that Swi/Snf is important for histone eviction at enhancers and that it also functions as a Pol II elongation factor.","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Oct","modification":"2025-04-21T14:52:18.643Z","creation":"2019-03-27T02:22:21Z"},"accession":"S-EPMC2168902","cross_references":{"pubmed":["17709398"],"doi":["10.1128/mcb.00717-07","10.1128/MCB.00717-07"]}}