{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Savransky V"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS"],"pagination":["1290-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2176090"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["175(12)"],"pubmed_abstract":["<h4>Rationale</h4>Obstructive sleep apnea, a condition leading to chronic intermittent hypoxia (CIH), is associated with hyperlipidemia, atherosclerosis, and a high cardiovascular risk. A causal link between obstructive sleep apnea and atherosclerosis has not been established.<h4>Objectives</h4>The objective of the present study was to examine whether CIH may induce atherosclerosis in C57BL/6J mice.<h4>Methods</h4>Forty male C57BL/6J mice, 8 weeks of age, were fed either a high-cholesterol diet or a regular chow diet and subjected either to CIH or intermittent air (control conditions) for 12 weeks.<h4>Measurements and main results</h4>Nine of 10 mice simultaneously exposed to CIH and high-cholesterol diet developed atherosclerotic lesions in the aortic origin and descending aorta. In contr"],"journal":["American journal of respiratory and critical care medicine"],"pubmed_title":["Chronic intermittent hypoxia induces atherosclerosis."],"pmcid":["PMC2176090"],"funding_grant_id":["HL68715","DK72488","HL80105","HL075646","HL79554"],"pubmed_authors":["Smith PL","Savransky V","Li J","Polotsky VY","Rodriguez A","Nanayakkara A","Bevans S"],"additional_accession":[]},"is_claimable":false,"name":"Chronic intermittent hypoxia induces atherosclerosis.","description":"<h4>Rationale</h4>Obstructive sleep apnea, a condition leading to chronic intermittent hypoxia (CIH), is associated with hyperlipidemia, atherosclerosis, and a high cardiovascular risk. A causal link between obstructive sleep apnea and atherosclerosis has not been established.<h4>Objectives</h4>The objective of the present study was to examine whether CIH may induce atherosclerosis in C57BL/6J mice.<h4>Methods</h4>Forty male C57BL/6J mice, 8 weeks of age, were fed either a high-cholesterol diet or a regular chow diet and subjected either to CIH or intermittent air (control conditions) for 12 weeks.<h4>Measurements and main results</h4>Nine of 10 mice simultaneously exposed to CIH and high-cholesterol diet developed atherosclerotic lesions in the aortic origin and descending aorta. In contr","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Jun","modification":"2026-03-16T16:40:57.029Z","creation":"2019-03-27T02:22:25Z"},"accession":"S-EPMC2176090","cross_references":{"pubmed":["17332479"],"doi":["10.1164/rccm.200612-1771OC","10.1164/rccm.200612-1771oc"]}}