biostudies-literatureSavransky VNIDDK NIH HHSNHLBI NIH HHS1290-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC2176090biostudies-literatureUnknown175(12)<h4>Rationale</h4>Obstructive sleep apnea, a condition leading to chronic intermittent hypoxia (CIH), is associated with hyperlipidemia, atherosclerosis, and a high cardiovascular risk. A causal link between obstructive sleep apnea and atherosclerosis has not been established.<h4>Objectives</h4>The objective of the present study was to examine whether CIH may induce atherosclerosis in C57BL/6J mice.<h4>Methods</h4>Forty male C57BL/6J mice, 8 weeks of age, were fed either a high-cholesterol diet or a regular chow diet and subjected either to CIH or intermittent air (control conditions) for 12 weeks.<h4>Measurements and main results</h4>Nine of 10 mice simultaneously exposed to CIH and high-cholesterol diet developed atherosclerotic lesions in the aortic origin and descending aorta. In contrAmerican journal of respiratory and critical care medicineChronic intermittent hypoxia induces atherosclerosis.PMC2176090HL68715DK72488HL80105HL075646HL79554Smith PLSavransky VLi JPolotsky VYRodriguez ANanayakkara ABevans SfalseChronic intermittent hypoxia induces atherosclerosis.<h4>Rationale</h4>Obstructive sleep apnea, a condition leading to chronic intermittent hypoxia (CIH), is associated with hyperlipidemia, atherosclerosis, and a high cardiovascular risk. A causal link between obstructive sleep apnea and atherosclerosis has not been established.<h4>Objectives</h4>The objective of the present study was to examine whether CIH may induce atherosclerosis in C57BL/6J mice.<h4>Methods</h4>Forty male C57BL/6J mice, 8 weeks of age, were fed either a high-cholesterol diet or a regular chow diet and subjected either to CIH or intermittent air (control conditions) for 12 weeks.<h4>Measurements and main results</h4>Nine of 10 mice simultaneously exposed to CIH and high-cholesterol diet developed atherosclerotic lesions in the aortic origin and descending aorta. In contr2007-01-01T00:00:00Z2007 Jun2026-03-16T16:40:57.029Z2019-03-27T02:22:25ZS-EPMC21760901733247910.1164/rccm.200612-1771OC10.1164/rccm.200612-1771oc