{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["177(1)"],"submitter":["Strange C"],"pubmed_abstract":["<h4>Rationale</h4>The presence of inflammatory cells on bronchoalveolar lavage is often used to predict disease activity and the need for therapy in systemic sclerosis-associated interstitial lung disease.<h4>Objectives</h4>To evaluate whether lavage cellularity identifies distinct subsets of disease and/or predicts cyclophosphamide responsiveness.<h4>Methods</h4>Patients underwent baseline lavage and/or high-resolution computed tomography as part of a randomized placebo-controlled trial of cyclophosphamide versus placebo (Scleroderma Lung Study) to determine the effect of therapy on forced vital capacity. Patients with 3% or greater polymorphonuclear and/or 2% or greater eosinophilic leukocytes on lavage and/or ground-glass opacification on computed tomography were eligible for enrollment"],"journal":["American journal of respiratory and critical care medicine"],"pagination":["91-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2176114"],"repository":["biostudies-literature"],"pubmed_title":["Bronchoalveolar lavage and response to cyclophosphamide in scleroderma interstitial lung disease."],"pmcid":["PMC2176114"],"pubmed_authors":["Furst DE","Silver RM","Elashoff RM","Goldin J","Chung J","Suh R","Smith EA","Bolster MB","Scleroderma Lung Study Research Group","Tashkin DP","Clements P","Theodore A","Strange C","Roth MD"],"additional_accession":[]},"is_claimable":false,"name":"Bronchoalveolar lavage and response to cyclophosphamide in scleroderma interstitial lung disease.","description":"<h4>Rationale</h4>The presence of inflammatory cells on bronchoalveolar lavage is often used to predict disease activity and the need for therapy in systemic sclerosis-associated interstitial lung disease.<h4>Objectives</h4>To evaluate whether lavage cellularity identifies distinct subsets of disease and/or predicts cyclophosphamide responsiveness.<h4>Methods</h4>Patients underwent baseline lavage and/or high-resolution computed tomography as part of a randomized placebo-controlled trial of cyclophosphamide versus placebo (Scleroderma Lung Study) to determine the effect of therapy on forced vital capacity. Patients with 3% or greater polymorphonuclear and/or 2% or greater eosinophilic leukocytes on lavage and/or ground-glass opacification on computed tomography were eligible for enrollment","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Jan","modification":"2025-04-04T08:38:44.488Z","creation":"2019-03-27T02:22:25Z"},"accession":"S-EPMC2176114","cross_references":{"pubmed":["17901414"],"doi":["10.1164/rccm.200705-655OC","10.1164/rccm.200705-655oc"]}}