{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["96(14)"],"submitter":["Roperch JP"],"pubmed_abstract":["We have previously described biological model systems for studying tumor suppression in which, by using H-1 parvovirus as a selective agent, cells with a strongly suppressed malignant phenotype (KS or US) were derived from malignant cell lines (K562 or U937). By using cDNA display on the K562/KS cells, 15 cDNAs were now isolated, corresponding to genes differentially regulated in tumor suppression. Of these, TSAP9 corresponds to a TCP-1 chaperonin, TSAP13 to a regulatory proteasome subunit, and TSAP21 to syntaxin 11, a vesicular trafficking molecule. The 15 cDNAs were used as a molecular fingerprint in different tumor-suppression models. We found that a similar pattern of differential regulation is shared by activation of p53, p21(Waf1), and the human homologue of Drosophila seven in absen"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["8070-3"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC22189"],"repository":["biostudies-literature"],"pubmed_title":["SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1)."],"pmcid":["PMC22189"],"pubmed_authors":["Nemani M","Dausset J","Pasturaud P","Telerman A","Lethrone F","Israeli D","Amson RB","Roperch JP","Prieur S","Gendron MC","Tuynder M","Oren M","Piouffre L"],"additional_accession":[]},"is_claimable":false,"name":"SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1).","description":"We have previously described biological model systems for studying tumor suppression in which, by using H-1 parvovirus as a selective agent, cells with a strongly suppressed malignant phenotype (KS or US) were derived from malignant cell lines (K562 or U937). By using cDNA display on the K562/KS cells, 15 cDNAs were now isolated, corresponding to genes differentially regulated in tumor suppression. Of these, TSAP9 corresponds to a TCP-1 chaperonin, TSAP13 to a regulatory proteasome subunit, and TSAP21 to syntaxin 11, a vesicular trafficking molecule. The 15 cDNAs were used as a molecular fingerprint in different tumor-suppression models. We found that a similar pattern of differential regulation is shared by activation of p53, p21(Waf1), and the human homologue of Drosophila seven in absen","dates":{"release":"1999-01-01T00:00:00Z","publication":"1999 Jul","modification":"2025-05-29T19:44:30.789Z","creation":"2019-03-27T00:17:49Z"},"accession":"S-EPMC22189","cross_references":{"pubmed":["10393949"],"doi":["10.1073/pnas.96.14.8070"]}}