{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["96(14)"],"submitter":["Morin-Surun MP"],"pubmed_abstract":["Most physiological effects of sigma1 receptor ligands are sensitive to pertussis toxin, suggesting a coupling with cell membrane-bound G proteins. However, the cloning of the sigma1 receptor has allowed the identification of an intracellular protein anchored on the endoplasmic reticulum. Here, we show, using the isolated adult guinea pig brainstem preparation, that activation of the sigma1 receptor results in its translocation from the cytosol to the vicinity of the cell membrane and induces a robust and rapid decrease in hypoglossal activity, which is mediated by phospholipase C. The subsequent activation of protein kinase C beta1 and beta2 isoforms and the phosphorylation of a protein of the same molecular weight as the cloned sigma1 receptor lead to a desensitization of the sigma1 motor"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["8196-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC22211"],"repository":["biostudies-literature"],"pubmed_title":["Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem."],"pmcid":["PMC22211"],"pubmed_authors":["Collin T","Baulieu EE","Monnet FP","Morin-Surun MP","Denavit-Saubie M"],"additional_accession":[]},"is_claimable":false,"name":"Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem.","description":"Most physiological effects of sigma1 receptor ligands are sensitive to pertussis toxin, suggesting a coupling with cell membrane-bound G proteins. However, the cloning of the sigma1 receptor has allowed the identification of an intracellular protein anchored on the endoplasmic reticulum. Here, we show, using the isolated adult guinea pig brainstem preparation, that activation of the sigma1 receptor results in its translocation from the cytosol to the vicinity of the cell membrane and induces a robust and rapid decrease in hypoglossal activity, which is mediated by phospholipase C. The subsequent activation of protein kinase C beta1 and beta2 isoforms and the phosphorylation of a protein of the same molecular weight as the cloned sigma1 receptor lead to a desensitization of the sigma1 motor","dates":{"release":"1999-01-01T00:00:00Z","publication":"1999 Jul","modification":"2025-05-29T19:44:31.429Z","creation":"2019-03-27T00:17:49Z"},"accession":"S-EPMC22211","cross_references":{"pubmed":["10393971"],"doi":["10.1073/pnas.96.14.8196"]}}