{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["62(Pt 8)"],"submitter":["Kitatani T"],"pubmed_abstract":["The crystal structure of NADP-dependent apo-glyceraldehyde-3-phosphate dehydrogenase (apo-GAPDH) from Synechococcus PCC 7942 is reported. The crystal structure was solved by molecular replacement and refined to an R of 21.7% and R(free) of 27.5% at 2.9 angstroms resolution. The structural features of apo-GAPDH are as follows. The S-loop has an extremely flexible conformation and the sulfate ion is only taken into the classical P(i) site. A structural comparison with holo-GAPDHs indicated that the S-loop fixation is essential in the discrimination of NADP and NAD molecules."],"journal":["Acta crystallographica. Section F, Structural biology and crystallization communications"],"pagination":["727-30"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2242934"],"repository":["biostudies-literature"],"pubmed_title":["Structure of apo-glyceraldehyde-3-phosphate dehydrogenase from Synechococcus PCC7942."],"pmcid":["PMC2242934"],"pubmed_authors":["Kitatani T","Tamoi M","Tada T","Nakamura Y","Shigeoka S","Wada K","Kinoshita T"],"additional_accession":[]},"is_claimable":false,"name":"Structure of apo-glyceraldehyde-3-phosphate dehydrogenase from Synechococcus PCC7942.","description":"The crystal structure of NADP-dependent apo-glyceraldehyde-3-phosphate dehydrogenase (apo-GAPDH) from Synechococcus PCC 7942 is reported. The crystal structure was solved by molecular replacement and refined to an R of 21.7% and R(free) of 27.5% at 2.9 angstroms resolution. The structural features of apo-GAPDH are as follows. The S-loop has an extremely flexible conformation and the sulfate ion is only taken into the classical P(i) site. A structural comparison with holo-GAPDHs indicated that the S-loop fixation is essential in the discrimination of NADP and NAD molecules.","dates":{"release":"2006-01-01T00:00:00Z","publication":"2006 Aug","modification":"2025-04-04T14:12:11.214Z","creation":"2019-03-27T00:12:56Z"},"accession":"S-EPMC2242934","cross_references":{"pubmed":["16880542"],"doi":["10.1107/S1744309106027916","10.1107/s1744309106027916"]}}