{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(2)"],"submitter":["Blanco S"],"pubmed_abstract":["<h4>Background</h4>Cellular biological responses to specific stimulation are determined by a balance among signaling pathways. Protein interactions are likely to modulate these pathways. Vaccinia-related kinase-2 (VRK2) is a novel human kinase that can modulate different signaling pathways.<h4>Principal findings</h4>We report that in vivo, the activity of JIP1-JNK complexes is downregulated by VRK2 in response to interleukin-1beta. Also the reduction of endogenous VRK2 with shRNA increases the transcriptional response to IL-1beta. The JIP1 scaffold protein assembles three consecutive members of a given MAPK pathway forming signaling complexes and their signal can be modulated by interactions with regulatory proteins that remain to be identified. Knocking-down JIP1 with siRNA resulted in el"],"journal":["PloS one"],"pagination":["e1660"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2243017"],"repository":["biostudies-literature"],"pubmed_title":["Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein."],"pmcid":["PMC2243017"],"pubmed_authors":["Sanz-Garcia M","Santos CR","Blanco S","Lazo PA"],"additional_accession":[]},"is_claimable":false,"name":"Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein.","description":"<h4>Background</h4>Cellular biological responses to specific stimulation are determined by a balance among signaling pathways. Protein interactions are likely to modulate these pathways. Vaccinia-related kinase-2 (VRK2) is a novel human kinase that can modulate different signaling pathways.<h4>Principal findings</h4>We report that in vivo, the activity of JIP1-JNK complexes is downregulated by VRK2 in response to interleukin-1beta. Also the reduction of endogenous VRK2 with shRNA increases the transcriptional response to IL-1beta. The JIP1 scaffold protein assembles three consecutive members of a given MAPK pathway forming signaling complexes and their signal can be modulated by interactions with regulatory proteins that remain to be identified. Knocking-down JIP1 with siRNA resulted in el","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Feb","modification":"2025-04-04T14:11:28.904Z","creation":"2019-03-26T23:02:35Z"},"accession":"S-EPMC2243017","cross_references":{"pubmed":["18286207"],"doi":["10.1371/journal.pone.0001660"]}}