biostudies-literatureChen JCNIGMS NIH HHS541-5https://www.ebi.ac.uk/biostudies/studies/S-EPMC2268516biostudies-literatureUnknown7(3)When the abundance of the FOX1 gene product is reduced, Chlamydomonas cells grow poorly in iron-deficient medium, but not in iron-replete medium, suggesting that FOX1-dependent iron uptake is a high-affinity pathway. Alternative pathways for iron assimilation, such as those involving ZIP family transporters IRT1 and IRT2, may be operational.Eukaryotic cellA ferroxidase encoded by FOX1 contributes to iron assimilation under conditions of poor iron nutrition in Chlamydomonas.PMC2268516R01 GM042143T32 GM007185R37 GM042143GM07185GM42143Chen JCKropat JHsieh SIMerchant SSfalseA ferroxidase encoded by FOX1 contributes to iron assimilation under conditions of poor iron nutrition in Chlamydomonas.When the abundance of the FOX1 gene product is reduced, Chlamydomonas cells grow poorly in iron-deficient medium, but not in iron-replete medium, suggesting that FOX1-dependent iron uptake is a high-affinity pathway. Alternative pathways for iron assimilation, such as those involving ZIP family transporters IRT1 and IRT2, may be operational.2008-01-01T00:00:00Z2008 Mar2025-04-19T16:49:12.824Z2019-03-27T02:44:27ZS-EPMC22685161824527510.1128/EC.00463-0710.1128/ec.00463-07