{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Pham NA"],"pubmed_abstract":["<h4>Background</h4>The pathogenesis of pancreatic ductal adenocarcinoma (PDAC) involves multi-stage development of molecular aberrations affecting signaling pathways that regulate cancer growth and progression. This study was performed to gain a better understanding of the abnormal signaling that occurs in PDAC compared with normal duct epithelia.<h4>Methods</h4>We performed immunohistochemistry on a tissue microarray of 26 PDAC, 13 normal appearing adjacent pancreatic ductal epithelia, and 12 normal non-PDAC ducts. We compared the levels of 18 signaling proteins including growth factor receptors, tumor suppressors and 13 of their putative downstream phosphorylated (p-) signal transducers in PDAC to those in normal ductal epithelia.<h4>Results</h4>The overall profiles of signaling protein "],"journal":["BMC cancer"],"pagination":["43"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2270852"],"repository":["biostudies-literature"],"pubmed_title":["Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis."],"pmcid":["PMC2270852"],"pubmed_authors":["Schwock J","Iakovlev V","Tsao MS","Pham NA","Hedley DW","Pond G"],"additional_accession":[]},"is_claimable":false,"name":"Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis.","description":"<h4>Background</h4>The pathogenesis of pancreatic ductal adenocarcinoma (PDAC) involves multi-stage development of molecular aberrations affecting signaling pathways that regulate cancer growth and progression. This study was performed to gain a better understanding of the abnormal signaling that occurs in PDAC compared with normal duct epithelia.<h4>Methods</h4>We performed immunohistochemistry on a tissue microarray of 26 PDAC, 13 normal appearing adjacent pancreatic ductal epithelia, and 12 normal non-PDAC ducts. We compared the levels of 18 signaling proteins including growth factor receptors, tumor suppressors and 13 of their putative downstream phosphorylated (p-) signal transducers in PDAC to those in normal ductal epithelia.<h4>Results</h4>The overall profiles of signaling protein ","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Feb","modification":"2026-03-16T16:40:01.882Z","creation":"2025-08-31T03:08:35.557Z"},"accession":"S-EPMC2270852","cross_references":{"pubmed":["18254976"],"doi":["10.1186/1471-2407-8-43"]}}