biostudies-literatureUnknown8Pham NA<h4>Background</h4>The pathogenesis of pancreatic ductal adenocarcinoma (PDAC) involves multi-stage development of molecular aberrations affecting signaling pathways that regulate cancer growth and progression. This study was performed to gain a better understanding of the abnormal signaling that occurs in PDAC compared with normal duct epithelia.<h4>Methods</h4>We performed immunohistochemistry on a tissue microarray of 26 PDAC, 13 normal appearing adjacent pancreatic ductal epithelia, and 12 normal non-PDAC ducts. We compared the levels of 18 signaling proteins including growth factor receptors, tumor suppressors and 13 of their putative downstream phosphorylated (p-) signal transducers in PDAC to those in normal ductal epithelia.<h4>Results</h4>The overall profiles of signaling protein BMC cancer43https://www.ebi.ac.uk/biostudies/studies/S-EPMC2270852biostudies-literatureImmunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis.PMC2270852Schwock JIakovlev VTsao MSPham NAHedley DWPond GfalseImmunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis.<h4>Background</h4>The pathogenesis of pancreatic ductal adenocarcinoma (PDAC) involves multi-stage development of molecular aberrations affecting signaling pathways that regulate cancer growth and progression. This study was performed to gain a better understanding of the abnormal signaling that occurs in PDAC compared with normal duct epithelia.<h4>Methods</h4>We performed immunohistochemistry on a tissue microarray of 26 PDAC, 13 normal appearing adjacent pancreatic ductal epithelia, and 12 normal non-PDAC ducts. We compared the levels of 18 signaling proteins including growth factor receptors, tumor suppressors and 13 of their putative downstream phosphorylated (p-) signal transducers in PDAC to those in normal ductal epithelia.<h4>Results</h4>The overall profiles of signaling protein 2008-01-01T00:00:00Z2008 Feb2026-03-16T16:40:01.882Z2025-08-31T03:08:35.557ZS-EPMC22708521825497610.1186/1471-2407-8-43