{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Meragelman TL"],"funding":["Intramural NIH HHS","NCI NIH HHS"],"pagination":["1133-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2288652"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["70(7)"],"pubmed_abstract":["Fractionation of cytotoxic extracts of specimens of a newly described sponge genus, Candidaspongia, has yielded the candidaspongiolides (3), a complex mixture of acyl esters of a macrolide related to tedanolide. The general structure of the candidaspongiolides was determined by analyses of various 2D NMR and MS data sets. The acyl ester components were identified by GC-MS analysis of the derived fatty acid methyl esters. The mixture could be selectively converted to the deacylated macrolide core (4) by enzymolysis with immobilized porcine lipase, with the structure of the candidaspongiolide core then secured by NMR and MS analysis. The candidaspongiolide mixture was potently cytotoxic, exhibiting a mean panel 50% growth inhibition (GI50) of 14 ng/mL in the National Cancer Institute's 60-cell-line in vitro antitumor screen."],"journal":["Journal of natural products"],"pubmed_title":["Candidaspongiolides, distinctive analogues of tedanolide from sponges of the genus Candidaspongia."],"pmcid":["PMC2288652"],"funding_grant_id":["Y99 CA999999","Z99 CA999999"],"pubmed_authors":["van Soest R","Meragelman TL","Boyd MR","Snader KM","Newman DJ","Heaton A","McKee TC","Murphy PT","Cardellina JH","Willis RH","Woldemichael GM"],"additional_accession":[]},"is_claimable":false,"name":"Candidaspongiolides, distinctive analogues of tedanolide from sponges of the genus Candidaspongia.","description":"Fractionation of cytotoxic extracts of specimens of a newly described sponge genus, Candidaspongia, has yielded the candidaspongiolides (3), a complex mixture of acyl esters of a macrolide related to tedanolide. The general structure of the candidaspongiolides was determined by analyses of various 2D NMR and MS data sets. The acyl ester components were identified by GC-MS analysis of the derived fatty acid methyl esters. The mixture could be selectively converted to the deacylated macrolide core (4) by enzymolysis with immobilized porcine lipase, with the structure of the candidaspongiolide core then secured by NMR and MS analysis. The candidaspongiolide mixture was potently cytotoxic, exhibiting a mean panel 50% growth inhibition (GI50) of 14 ng/mL in the National Cancer Institute's 60-cell-line in vitro antitumor screen.","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Jul","modification":"2024-11-12T19:37:29.559Z","creation":"2019-03-27T02:44:38Z"},"accession":"S-EPMC2288652","cross_references":{"pubmed":["17564468"],"doi":["10.1021/np0700974"]}}