{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["94(16)"],"submitter":["Stewart M"],"pubmed_abstract":["The til-1 locus was identified as a common retroviral integration site in virus-accelerated lymphomas of CD2-myc transgenic mice. We now show that viral insertions at til-1 lead to transcriptional activation of PEBP2alphaA (CBFA1), a transcription factor related to the Drosophila segmentation gene product, Runt. Insertions are upstream and in the opposite orientation to the gene and appear to activate a variant promoter that is normally silent in T cells. Activity of this promoter was detected in rodent osteogenic sarcoma cells and primary osteoblasts, implicating bone as the normal site of promoter activity. The isoforms encoded by the activated gene all encompass the conserved runt DNA-binding domain and share a novel N terminus different from the previously reported PEBP2alphaA products"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["8646-51"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC23059"],"repository":["biostudies-literature"],"pubmed_title":["Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene."],"pmcid":["PMC23059"],"pubmed_authors":["O'Hara M","Cameron E","Stewart M","Neil JC","Hu M","Blyth K","Terry A","Baxter E","Onions DE"],"additional_accession":[]},"is_claimable":false,"name":"Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene.","description":"The til-1 locus was identified as a common retroviral integration site in virus-accelerated lymphomas of CD2-myc transgenic mice. We now show that viral insertions at til-1 lead to transcriptional activation of PEBP2alphaA (CBFA1), a transcription factor related to the Drosophila segmentation gene product, Runt. Insertions are upstream and in the opposite orientation to the gene and appear to activate a variant promoter that is normally silent in T cells. Activity of this promoter was detected in rodent osteogenic sarcoma cells and primary osteoblasts, implicating bone as the normal site of promoter activity. The isoforms encoded by the activated gene all encompass the conserved runt DNA-binding domain and share a novel N terminus different from the previously reported PEBP2alphaA products","dates":{"release":"1997-01-01T00:00:00Z","publication":"1997 Aug","modification":"2025-04-26T23:41:17.989Z","creation":"2019-03-27T00:17:50Z"},"accession":"S-EPMC23059","cross_references":{"pubmed":["9238031"],"doi":["10.1073/pnas.94.16.8646"]}}