{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Flatt T"],"funding":["NIA NIH HHS","Howard Hughes Medical Institute"],"pagination":["6368-73"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2359818"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["105(17)"],"pubmed_abstract":["Ablation of germ-line precursor cells in Caenorhabditis elegans extends lifespan by activating DAF-16, a forkhead transcription factor (FOXO) repressed by insulin/insulin-like growth factor (IGF) signaling (IIS). Signals from the gonad might thus regulate whole-organism aging by modulating IIS. To date, the details of this systemic regulation of aging by the reproductive system are not understood, and it is unknown whether such effects are evolutionarily conserved. Here we report that eliminating germ cells (GCs) in Drosophila melanogaster increases lifespan and modulates insulin signaling. Long-lived germ-line-less flies show increased production of Drosophila insulin-like peptides (dilps) and hypoglycemia but simultaneously exhibit several characteristics of IIS impedance, as indicated b"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Drosophila germ-line modulation of insulin signaling and lifespan."],"pmcid":["PMC2359818"],"funding_grant_id":["R01 AG024360","R01 AG021953","R01 AG028092","AG024360","AG021953","R37 AG024360"],"pubmed_authors":["Cumbers J","Min KJ","Villa-Cuesta E","Jones DL","Flatt T","Tatar M","D'Alterio C","Lehmann R"],"additional_accession":[]},"is_claimable":false,"name":"Drosophila germ-line modulation of insulin signaling and lifespan.","description":"Ablation of germ-line precursor cells in Caenorhabditis elegans extends lifespan by activating DAF-16, a forkhead transcription factor (FOXO) repressed by insulin/insulin-like growth factor (IGF) signaling (IIS). Signals from the gonad might thus regulate whole-organism aging by modulating IIS. To date, the details of this systemic regulation of aging by the reproductive system are not understood, and it is unknown whether such effects are evolutionarily conserved. Here we report that eliminating germ cells (GCs) in Drosophila melanogaster increases lifespan and modulates insulin signaling. Long-lived germ-line-less flies show increased production of Drosophila insulin-like peptides (dilps) and hypoglycemia but simultaneously exhibit several characteristics of IIS impedance, as indicated b","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Apr","modification":"2026-03-16T16:24:38.725Z","creation":"2025-08-30T03:09:45.324Z"},"accession":"S-EPMC2359818","cross_references":{"pubmed":["18434551"],"doi":["10.1073/pnas.0709128105"]}}