{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["94(1)"],"submitter":["Puisieux A"],"pubmed_abstract":["A major obstacle to the expansion of abnormal cells with significant proliferative potential is the induction of programmed cell death. Consequently, oncogene-driven hyperproliferation must be associated with apoptosis inhibition to allow malignant outgrowth. The oncogenic cooperation of N-Myc and Twist-1 in the development of neuroblastoma, the most common and deadly solid tumour of childhood, perfectly illustrates such a process. N-Myc promotes cell proliferation, whereas Twist-1 counteracts its pro-apoptotic properties by knocking-down the ARF/p53 pathway. On the basis of numerous recent studies reporting its overexpression in a variety of human cancers, we discuss in this review the role of Twist-1 as a potent inhibitor of the cell safety programs engaged in response to an abnormal mit"],"journal":["British journal of cancer"],"pagination":["13-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2361066"],"repository":["biostudies-literature"],"pubmed_title":["A twist for survival and cancer progression."],"pmcid":["PMC2361066"],"pubmed_authors":["Ansieau S","Puisieux A","Valsesia-Wittmann S"],"additional_accession":[]},"is_claimable":false,"name":"A twist for survival and cancer progression.","description":"A major obstacle to the expansion of abnormal cells with significant proliferative potential is the induction of programmed cell death. Consequently, oncogene-driven hyperproliferation must be associated with apoptosis inhibition to allow malignant outgrowth. The oncogenic cooperation of N-Myc and Twist-1 in the development of neuroblastoma, the most common and deadly solid tumour of childhood, perfectly illustrates such a process. N-Myc promotes cell proliferation, whereas Twist-1 counteracts its pro-apoptotic properties by knocking-down the ARF/p53 pathway. On the basis of numerous recent studies reporting its overexpression in a variety of human cancers, we discuss in this review the role of Twist-1 as a potent inhibitor of the cell safety programs engaged in response to an abnormal mit","dates":{"release":"2006-01-01T00:00:00Z","publication":"2006 Jan","modification":"2025-04-18T15:08:57.156Z","creation":"2019-03-27T02:44:55Z"},"accession":"S-EPMC2361066","cross_references":{"pubmed":["16306876"],"doi":["10.1038/sj.bjc.6602876"]}}