{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao YL"],"funding":["NIEHS NIH HHS","NCI NIH HHS"],"pagination":["1923-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2375424"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["86(12)"],"pubmed_abstract":["Interaction between cell and extracellular matrix plays a crucial role in tumour invasion and metastasis. Using an immortalised human bronchial epithelial (BEP2D) cell model, the study here shows that expression of Betaig-h3 gene, which encodes a secreted adhesion molecule induced by transforming growth factor-beta, is markedly decreased in several independently generated, radiation-induced tumour cell lines (TL1-TL5) relative to parental BEP2D cells. Transfection of Betaig-h3 gene into tumour cells resulted in a significant reduction in tumour growth. While integrin receptor alpha5beta1 was overexpressed in tumour cells, its expression was corrected to the level found in control BEP2D cells after Betaig-h3 transfection. These data suggest that Betaig-h3 gene is involved in tumour progress"],"journal":["British journal of cancer"],"pubmed_title":["Overexpression of Betaig-h3 gene downregulates integrin alpha5beta1 and suppresses tumorigenicity in radiation-induced tumorigenic human bronchial epithelial cells."],"pmcid":["PMC2375424"],"funding_grant_id":["P01 CA049062","ES07890","CA49062"],"pubmed_authors":["Zhao YL","Hei TK","Piao CQ"],"additional_accession":[]},"is_claimable":false,"name":"Overexpression of Betaig-h3 gene downregulates integrin alpha5beta1 and suppresses tumorigenicity in radiation-induced tumorigenic human bronchial epithelial cells.","description":"Interaction between cell and extracellular matrix plays a crucial role in tumour invasion and metastasis. Using an immortalised human bronchial epithelial (BEP2D) cell model, the study here shows that expression of Betaig-h3 gene, which encodes a secreted adhesion molecule induced by transforming growth factor-beta, is markedly decreased in several independently generated, radiation-induced tumour cell lines (TL1-TL5) relative to parental BEP2D cells. Transfection of Betaig-h3 gene into tumour cells resulted in a significant reduction in tumour growth. While integrin receptor alpha5beta1 was overexpressed in tumour cells, its expression was corrected to the level found in control BEP2D cells after Betaig-h3 transfection. These data suggest that Betaig-h3 gene is involved in tumour progress","dates":{"release":"2002-01-01T00:00:00Z","publication":"2002 Jun","modification":"2025-04-25T23:07:34.928Z","creation":"2019-06-06T18:02:06Z"},"accession":"S-EPMC2375424","cross_references":{"pubmed":["12085188"],"doi":["10.1038/sj.bjc.6600304"]}}