{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schuster EF"],"funding":["Medical Research Council","Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["R125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2394774"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(6)"],"pubmed_abstract":["The probe sequence of short oligonucleotides in Affymetrix microarray experiments can have a significant influence on present/absent calls of probesets with absent target transcripts. Probesets enriched for central Ts and depleted of central As in the perfect-match probes tend to be falsely classified as having present transcripts. Correction of non-specific binding for both perfect-match and mismatch probes using probe-sequence models can partially remove the probe-sequence bias and result in better performance of the MAS 5.0 algorithm."],"journal":["Genome biology"],"pubmed_title":["Correcting for sequence biases in present/absent calls."],"pmcid":["PMC2394774"],"funding_grant_id":["G9900989","SF19106"],"pubmed_authors":["Blanc E","Schuster EF","Partridge L","Thornton JM"],"additional_accession":[]},"is_claimable":false,"name":"Correcting for sequence biases in present/absent calls.","description":"The probe sequence of short oligonucleotides in Affymetrix microarray experiments can have a significant influence on present/absent calls of probesets with absent target transcripts. Probesets enriched for central Ts and depleted of central As in the perfect-match probes tend to be falsely classified as having present transcripts. Correction of non-specific binding for both perfect-match and mismatch probes using probe-sequence models can partially remove the probe-sequence bias and result in better performance of the MAS 5.0 algorithm.","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007","modification":"2025-04-19T07:40:52.147Z","creation":"2019-03-27T00:15:12Z"},"accession":"S-EPMC2394774","cross_references":{"pubmed":["17594492"],"doi":["10.1186/gb-2007-8-6-r125"]}}