{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fox EM"],"funding":["NIAID NIH HHS","PHS HHS"],"pagination":["671-82"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2399893"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(5)"],"pubmed_abstract":["A gene, sirZ, encoding a Zn(II)(2)Cys(6) DNA binding protein is present in a cluster of genes responsible for the biosynthesis of the epipolythiodioxopiperazine (ETP) toxin, sirodesmin PL in the ascomycete plant pathogen, Leptosphaeria maculans. RNA-mediated silencing of sirZ gives rise to transformants that produce only residual amounts of sirodesmin PL and display a decrease in the transcription of several sirodesmin PL biosynthetic genes. This indicates that SirZ is a major regulator of this gene cluster. Proteins similar to SirZ are encoded in the gliotoxin biosynthetic gene cluster of Aspergillus fumigatus (gliZ) and in an ETP-like cluster in Penicillium lilacinoechinulatum (PlgliZ). Despite its high level of sequence similarity to gliZ, PlgliZ is unable to complement the gliotoxin-de"],"journal":["Fungal genetics and biology : FG & B"],"pubmed_title":["A Zn(II)2Cys6 DNA binding protein regulates the sirodesmin PL biosynthetic gene cluster in Leptosphaeria maculans."],"pmcid":["PMC2399893"],"funding_grant_id":["R01 AI065728-01A1","R01 AI065728","1 R01 AL065728-01"],"pubmed_authors":["Keller NP","Gardiner DM","Howlett BJ","Fox EM"],"additional_accession":[]},"is_claimable":false,"name":"A Zn(II)2Cys6 DNA binding protein regulates the sirodesmin PL biosynthetic gene cluster in Leptosphaeria maculans.","description":"A gene, sirZ, encoding a Zn(II)(2)Cys(6) DNA binding protein is present in a cluster of genes responsible for the biosynthesis of the epipolythiodioxopiperazine (ETP) toxin, sirodesmin PL in the ascomycete plant pathogen, Leptosphaeria maculans. RNA-mediated silencing of sirZ gives rise to transformants that produce only residual amounts of sirodesmin PL and display a decrease in the transcription of several sirodesmin PL biosynthetic genes. This indicates that SirZ is a major regulator of this gene cluster. Proteins similar to SirZ are encoded in the gliotoxin biosynthetic gene cluster of Aspergillus fumigatus (gliZ) and in an ETP-like cluster in Penicillium lilacinoechinulatum (PlgliZ). Despite its high level of sequence similarity to gliZ, PlgliZ is unable to complement the gliotoxin-de","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 May","modification":"2025-04-04T19:30:53.467Z","creation":"2019-03-27T00:15:19Z"},"accession":"S-EPMC2399893","cross_references":{"pubmed":["18023597"],"doi":["10.1016/j.fgb.2007.10.005"]}}