{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pullinger CR"],"funding":["NCRR NIH HHS"],"pagination":["1846-54"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2444008"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["49(8)"],"pubmed_abstract":["Apolipoprotein A-V (apoA-V) is an important regulator of plasma levels of triglyceride (TG) in mice. In humans, APOA5 genetic variation is associated with TG in several populations. In this study, we determined the effects of the p.185Gly>Cys (c.553G>T; rs2075291) polymorphism on plasma TG levels in subjects of Chinese ancestry living in the United States and in a group of non-Chinese Asian ancestry. The frequency of the less common cysteine allele was 4-fold higher (15.1% vs. 3.7%) in Chinese high-TG subjects compared with a low-TG group (Chi-square = 20.2; P < 0.0001), corresponding with a 4.45 times higher risk of hypertriglyceridemia (95% confidence interval, 2.18-9.07; P < 0.001). These results were replicated in the non-Chinese Asians. Heterozygosity was associated, in the high-TG gr"],"journal":["Journal of lipid research"],"pubmed_title":["An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients."],"pmcid":["PMC2444008"],"funding_grant_id":["KL2 RR 024130","KL2 RR024130"],"pubmed_authors":["Dallinga-Thie GM","Nakajima K","Green LL","Aouizerat BE","Sijbrands EJ","Poon A","Kane JP","Kwok PY","Hattori H","Pullinger CR","Frost PH","Malloy MJ","Havel RJ","Movsesyan I","Durlach V"],"additional_accession":[]},"is_claimable":false,"name":"An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients.","description":"Apolipoprotein A-V (apoA-V) is an important regulator of plasma levels of triglyceride (TG) in mice. In humans, APOA5 genetic variation is associated with TG in several populations. In this study, we determined the effects of the p.185Gly>Cys (c.553G>T; rs2075291) polymorphism on plasma TG levels in subjects of Chinese ancestry living in the United States and in a group of non-Chinese Asian ancestry. The frequency of the less common cysteine allele was 4-fold higher (15.1% vs. 3.7%) in Chinese high-TG subjects compared with a low-TG group (Chi-square = 20.2; P < 0.0001), corresponding with a 4.45 times higher risk of hypertriglyceridemia (95% confidence interval, 2.18-9.07; P < 0.001). These results were replicated in the non-Chinese Asians. Heterozygosity was associated, in the high-TG gr","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Aug","modification":"2026-04-30T22:22:27.18Z","creation":"2026-04-07T16:23:05.233Z"},"accession":"S-EPMC2444008","cross_references":{"pubmed":["18441017"],"doi":["10.1194/jlr.p800011-jlr200","10.1194/jlr.P800011-JLR200"]}}