{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2(7)"],"submitter":["Galvan-Moroyoqui JM"],"pubmed_abstract":["<h4>Background</h4>Mixed intestinal infections with Entamoeba histolytica, Entamoeba dispar and bacteria with exacerbated manifestations of disease are common in regions where amoebiasis is endemic. However, amoeba-bacteria interactions remain largely unexamined.<h4>Methodology</h4>Trophozoites of E. histolytica and E. dispar were co-cultured with enteropathogenic bacteria strains Escherichia coli (EPEC), Shigella dysenteriae and a commensal Escherichia coli. Amoebae that phagocytosed bacteria were tested for a cytopathic effect on epithelial cell monolayers. Cysteine proteinase activity, adhesion and cell surface concentration of Gal/GalNAc lectin were analyzed in amoebae showing increased virulence. Structural and functional changes and induction of IL-8 expression were determined in epi"],"journal":["PLoS neglected tropical diseases"],"pagination":["e266"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2447883"],"repository":["biostudies-literature"],"pubmed_title":["The interplay between Entamoeba and enteropathogenic bacteria modulates epithelial cell damage."],"pmcid":["PMC2447883"],"pubmed_authors":["Franco E","Meza I","Del Carmen Dominguez-Robles M","Galvan-Moroyoqui JM"],"additional_accession":[]},"is_claimable":false,"name":"The interplay between Entamoeba and enteropathogenic bacteria modulates epithelial cell damage.","description":"<h4>Background</h4>Mixed intestinal infections with Entamoeba histolytica, Entamoeba dispar and bacteria with exacerbated manifestations of disease are common in regions where amoebiasis is endemic. However, amoeba-bacteria interactions remain largely unexamined.<h4>Methodology</h4>Trophozoites of E. histolytica and E. dispar were co-cultured with enteropathogenic bacteria strains Escherichia coli (EPEC), Shigella dysenteriae and a commensal Escherichia coli. Amoebae that phagocytosed bacteria were tested for a cytopathic effect on epithelial cell monolayers. Cysteine proteinase activity, adhesion and cell surface concentration of Gal/GalNAc lectin were analyzed in amoebae showing increased virulence. Structural and functional changes and induction of IL-8 expression were determined in epi","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Jul","modification":"2025-04-04T18:33:48.182Z","creation":"2019-03-27T00:15:45Z"},"accession":"S-EPMC2447883","cross_references":{"pubmed":["18648517"],"doi":["10.1371/journal.pntd.0000266"]}}