{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nishizawa K"],"funding":["NIAID NIH HHS"],"pagination":["14897-902"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC24547"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["95(25)"],"pubmed_abstract":["An intracellular protein termed CD2 binding protein 2 (CD2BP2), which binds to a site containing two PPPGHR segments within the cytoplasmic region of CD2, was identified. Mutagenesis and NMR analysis demonstrated that the CD2 binding region of CD2BP2 includes a 17-aa motif (GPY[orF]xxxxM[orV]xxWxxx GYF), also found in several yeast and Caenorhabditis elegans proteins of unknown function. In Jurkat T cells, over-expression of the isolated CD2BP2 domain binding to CD2 enhances the production of interleukin 2 on crosslinking of CD2 but not the T cell receptor. Hence, a proline-binding module distinct from SH3 and WW domains regulates protein-protein interactions."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation."],"pmcid":["PMC24547"],"funding_grant_id":["AI27581","AI21226"],"pubmed_authors":["Freund C","Li J","Nishizawa K","Wagner G","Reinherz EL"],"additional_accession":[]},"is_claimable":false,"name":"Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation.","description":"An intracellular protein termed CD2 binding protein 2 (CD2BP2), which binds to a site containing two PPPGHR segments within the cytoplasmic region of CD2, was identified. Mutagenesis and NMR analysis demonstrated that the CD2 binding region of CD2BP2 includes a 17-aa motif (GPY[orF]xxxxM[orV]xxWxxx GYF), also found in several yeast and Caenorhabditis elegans proteins of unknown function. In Jurkat T cells, over-expression of the isolated CD2BP2 domain binding to CD2 enhances the production of interleukin 2 on crosslinking of CD2 but not the T cell receptor. Hence, a proline-binding module distinct from SH3 and WW domains regulates protein-protein interactions.","dates":{"release":"1998-01-01T00:00:00Z","publication":"1998 Dec","modification":"2025-04-26T23:39:08.441Z","creation":"2019-03-27T00:17:52Z"},"accession":"S-EPMC24547","cross_references":{"pubmed":["9843987"],"doi":["10.1073/pnas.95.25.14897"]}}