{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cao S"],"funding":["FIC NIH HHS"],"pagination":["1064-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2464365"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["70(6)"],"pubmed_abstract":["Bioassay-guided fractionation of an ethanol extract obtained from the Madagascar plant Elaeodendron sp. led to the isolation of two new cardenolides, elaeodendrosides T and U (1 and 2). The structures of the new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 3, 4, and 5 showed significant antiproliferative activity against A2780 human ovarian cancer cells with IC50 values of 0.085, 0.019, 0.19, and 0.10 microM, respectively, while compounds 2 and 6 were less active."],"journal":["Journal of natural products"],"pubmed_title":["Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1)."],"pmcid":["PMC2464365"],"funding_grant_id":["U01 TW000313-07","U01 TW00313","U01 TW000313"],"pubmed_authors":["Miller JS","Suh EM","Brodie PJ","Kingston DG","Rasamison VE","Rakotobe E","Cao S","Callmander MW","TenDyke K","Randrianasolo S","Ratovoson F"],"additional_accession":[]},"is_claimable":false,"name":"Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1).","description":"Bioassay-guided fractionation of an ethanol extract obtained from the Madagascar plant Elaeodendron sp. led to the isolation of two new cardenolides, elaeodendrosides T and U (1 and 2). The structures of the new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 3, 4, and 5 showed significant antiproliferative activity against A2780 human ovarian cancer cells with IC50 values of 0.085, 0.019, 0.19, and 0.10 microM, respectively, while compounds 2 and 6 were less active.","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Jun","modification":"2020-10-31T09:42:37Z","creation":"2019-03-27T00:15:49Z"},"accession":"S-EPMC2464365","cross_references":{"pubmed":["17547460"],"doi":["10.1021/np0701428"]}}