{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Barton A"],"funding":["Versus Arthritis","Medical Research Council","Wellcome Trust"],"pagination":["2274-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2465799"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(15)"],"pubmed_abstract":["Rheumatoid arthritis (RA) is an archetypal, common, complex autoimmune disease with both genetic and environmental contributions to disease aetiology. Two novel RA susceptibility loci have been reported from recent genome-wide and candidate gene association studies. We, therefore, investigated the evidence for association of the STAT4 and TRAF1/C5 loci with RA using imputed data from the Wellcome Trust Case Control Consortium (WTCCC). No evidence for association of variants mapping to the TRAF1/C5 gene was detected in the 1860 RA cases and 2930 control samples tested in that study. Variants mapping to the STAT4 gene did show evidence for association (rs7574865, P = 0.04). Given the association of the TRAF1/C5 locus in two previous large case-control series from populations of European desc"],"journal":["Human molecular genetics"],"pubmed_title":["Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility."],"pmcid":["PMC2465799"],"funding_grant_id":["17552","G0000934","18475","090532"],"pubmed_authors":["Stevens HE","Hordon L","Nimmo ER","Cardin NJ","Bentley D","McGuffin P","Taylor L","Mathew CG","Groves CJ","Lango H","Kirov G","Maqbool A","Xue M","Su Z","Gibbons L","Ferrier IN","Easton D","Vannberg F","Walker M","Braga Marcano CA","Gordon-Smith K","Williamson R","Jarret S","Forbes A","Melsom R","Doherty S","Widden C","Cant B","McArdle WL","Zeggini E","Jolley JD","Jewell DP","Hill AV","Winzer T","Young AH","Munroe PB","Seal S","Reece R","Sirugo G","Timpson NJ","Parkes M","Donnelly P","Potter C","Brown MJ","Stratton MR","Hinks A","Bradbury LA","Pickles D","Hocking L","Brown MA","Franklyn JA","Heard J","Plant D","Quinn M","St Clair D","Knight AS","Dunger DB","McGonagle D","Green J","Holmans PA","Dominiczak A","Rayner NW","Green M","Onipinla A","Lathrop GM","Corscadden D","Drummond H","Prescott NJ","Nunns C","Gill A","Taylor NC","Attwood AP","Fraser C","Jones RW","John SL","Firth J","Koch K","Inouye M","Potters S","Worthington J","Pointon JJ","Hussey JM","YEAR consortium","Spencer CC","Burke B","Martin SG","Gwilliam R","Prowse CV","Evans D","Tremelling M","Samani NJ","Owen MJ","Sanderson J","Jones L","Robinson JI","Wallace C","Lewis C","Kwiatkowski DP","Bumpstead SJ","Walker NM","Stevens S","Barton A","Newport M","Withers D","Keenan AM","Henshaw K","Mohiuddin MK","Silman AJ","Dixon RJ","Mangino M","Huson G","Nam J","Perry JR","Morris AP","Elkin A","Hitman GA","Eyre S","Everson U","Ball SG","Gungadoo J","Marchini JL","McCarthy MI","Yuldasheva N","Hider SL","Ring SM","Conway D","Rockett KA","Vukcevic D","Bredin F","Duncanson A","Emery P","Hinks AM","Adebajo A","Moskvina V","Sawcer SJ","Barbour J","Ke X","Satsangi J","Pereira-Gale J","Green EK","Frayling TM","Martin M","Neville B","Meech E","Gilbert PD","Farrar C","The Biologics in RA Genetics and Genomics Study Syndicate BRAGGS","Rashid LH","Marinou I","Lyons E","Hall AS","Connell J","Reid DM","Hattersley AT","Newhouse SJ","Pease C","Tobin MD","Helliwell P","Compston A","Thomas C","O'Donovan MC","Gough A","Whittaker P","Clayton DG","Deloukas P","Ferreira T","Iles MM","Ouwehand WH","Lees CW","Burton PR","Thomson W","Walters GR","Kitcheman J","Breast Cancer Susceptibility Collaboration","Farmer A","Bruce IN","Symmons DP","Elliott KS","Jallow M","Gough SC","Karim Z","Davison D","Weedon MN","Hunt SE","Balmforth AJ","Wellcome Trust Case Control Consortium","Lee KL","Cox S","Chaney A","Simmonds MJ","Fairclough A","Bowes J","Cardon LR","Braund PS","Todhunter CE","Ghori MJ","Hammond A","Bishop DT","Ahmad T","Goris A","Madden J","Donovan H","Hensor E","Lindgren CM","Brown C","Howie BN","Fisher SA","Boorman JP","Ban M","Mansfield JC","Teo YY","Nikolov I","Wordsworth P","Barrett JH","Keniry A","Webster J","Breen G","Barrett JC","Rahman N","McGinnis R","Jones IR","Farrall M","Hamshere ML","Rhys-Evans B","Todd JA","Freathy RM","Harvey A","Bejarano V","Heward JM","Widmer B","Leung HT","Harrison P","Ravindrarajah R","Watkins NA","Padwell B","Caesar S","Pembrey M","Nutland S","Wilson AG","Collier DA","Thompson JR","Strachan DP","Downes K","King H","Morgan A","Onnie CM","Dobson R","King E","Groze D","Caulfield M","Shields BM","Craddock N","Conaghan P","Isdale A","Steer S","Smith S","Hallgrimsdottir IB","Sigsworth L","Cummings FR"],"additional_accession":[]},"is_claimable":false,"name":"Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.","description":"Rheumatoid arthritis (RA) is an archetypal, common, complex autoimmune disease with both genetic and environmental contributions to disease aetiology. Two novel RA susceptibility loci have been reported from recent genome-wide and candidate gene association studies. We, therefore, investigated the evidence for association of the STAT4 and TRAF1/C5 loci with RA using imputed data from the Wellcome Trust Case Control Consortium (WTCCC). No evidence for association of variants mapping to the TRAF1/C5 gene was detected in the 1860 RA cases and 2930 control samples tested in that study. Variants mapping to the STAT4 gene did show evidence for association (rs7574865, P = 0.04). Given the association of the TRAF1/C5 locus in two previous large case-control series from populations of European desc","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Aug","modification":"2026-04-29T11:37:19.981Z","creation":"2019-03-27T00:15:50Z"},"accession":"S-EPMC2465799","cross_references":{"pubmed":["18434327"],"doi":["10.1093/hmg/ddn128"]}}