biostudies-literatureBarton AVersus ArthritisMedical Research CouncilWellcome Trust2274-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC2465799biostudies-literatureUnknown17(15)Rheumatoid arthritis (RA) is an archetypal, common, complex autoimmune disease with both genetic and environmental contributions to disease aetiology. Two novel RA susceptibility loci have been reported from recent genome-wide and candidate gene association studies. We, therefore, investigated the evidence for association of the STAT4 and TRAF1/C5 loci with RA using imputed data from the Wellcome Trust Case Control Consortium (WTCCC). No evidence for association of variants mapping to the TRAF1/C5 gene was detected in the 1860 RA cases and 2930 control samples tested in that study. Variants mapping to the STAT4 gene did show evidence for association (rs7574865, P = 0.04). Given the association of the TRAF1/C5 locus in two previous large case-control series from populations of European descHuman molecular geneticsRe-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.PMC246579917552G000093418475090532Stevens HEHordon LNimmo ERCardin NJBentley DMcGuffin PTaylor LMathew CGGroves CJLango HKirov GMaqbool AXue MSu ZGibbons LFerrier INEaston DVannberg FWalker MBraga Marcano CAGordon-Smith KWilliamson RJarret SForbes AMelsom RDoherty SWidden CCant BMcArdle WLZeggini EJolley JDJewell DPHill AVWinzer TYoung AHMunroe PBSeal SReece RSirugo GTimpson NJParkes MDonnelly PPotter CBrown MJStratton MRHinks ABradbury LAPickles DHocking LBrown MAFranklyn JAHeard JPlant DQuinn MSt Clair DKnight ASDunger DBMcGonagle DGreen JHolmans PADominiczak ARayner NWGreen MOnipinla ALathrop GMCorscadden DDrummond HPrescott NJNunns CGill ATaylor NCAttwood APFraser CJones RWJohn SLFirth JKoch KInouye MPotters SWorthington JPointon JJHussey JMYEAR consortiumSpencer CCBurke BMartin SGGwilliam RProwse CVEvans DTremelling MSamani NJOwen MJSanderson JJones LRobinson JIWallace CLewis CKwiatkowski DPBumpstead SJWalker NMStevens SBarton ANewport MWithers DKeenan AMHenshaw KMohiuddin MKSilman AJDixon RJMangino MHuson GNam JPerry JRMorris APElkin AHitman GAEyre SEverson UBall SGGungadoo JMarchini JLMcCarthy MIYuldasheva NHider SLRing SMConway DRockett KAVukcevic DBredin FDuncanson AEmery PHinks AMAdebajo AMoskvina VSawcer SJBarbour JKe XSatsangi JPereira-Gale JGreen EKFrayling TMMartin MNeville BMeech EGilbert PDFarrar CThe Biologics in RA Genetics and Genomics Study Syndicate BRAGGSRashid LHMarinou ILyons EHall ASConnell JReid DMHattersley ATNewhouse SJPease CTobin MDHelliwell PCompston AThomas CO'Donovan MCGough AWhittaker PClayton DGDeloukas PFerreira TIles MMOuwehand WHLees CWBurton PRThomson WWalters GRKitcheman JBreast Cancer Susceptibility CollaborationFarmer ABruce INSymmons DPElliott KSJallow MGough SCKarim ZDavison DWeedon MNHunt SEBalmforth AJWellcome Trust Case Control ConsortiumLee KLCox SChaney ASimmonds MJFairclough ABowes JCardon LRBraund PSTodhunter CEGhori MJHammond ABishop DTAhmad TGoris AMadden JDonovan HHensor ELindgren CMBrown CHowie BNFisher SABoorman JPBan MMansfield JCTeo YYNikolov IWordsworth PBarrett JHKeniry AWebster JBreen GBarrett JCRahman NMcGinnis RJones IRFarrall MHamshere MLRhys-Evans BTodd JAFreathy RMHarvey ABejarano VHeward JMWidmer BLeung HTHarrison PRavindrarajah RWatkins NAPadwell BCaesar SPembrey MNutland SWilson AGCollier DAThompson JRStrachan DPDownes KKing HMorgan AOnnie CMDobson RKing EGroze DCaulfield MShields BMCraddock NConaghan PIsdale ASteer SSmith SHallgrimsdottir IBSigsworth LCummings FRfalseRe-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.Rheumatoid arthritis (RA) is an archetypal, common, complex autoimmune disease with both genetic and environmental contributions to disease aetiology. Two novel RA susceptibility loci have been reported from recent genome-wide and candidate gene association studies. We, therefore, investigated the evidence for association of the STAT4 and TRAF1/C5 loci with RA using imputed data from the Wellcome Trust Case Control Consortium (WTCCC). No evidence for association of variants mapping to the TRAF1/C5 gene was detected in the 1860 RA cases and 2930 control samples tested in that study. Variants mapping to the STAT4 gene did show evidence for association (rs7574865, P = 0.04). Given the association of the TRAF1/C5 locus in two previous large case-control series from populations of European desc2008-01-01T00:00:00Z2008 Aug2026-04-29T11:37:19.981Z2019-03-27T00:15:50ZS-EPMC24657991843432710.1093/hmg/ddn128