{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mitchell PS"],"funding":["NIDDK NIH HHS","NCI NIH HHS"],"pagination":["10513-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2492472"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["105(30)"],"pubmed_abstract":["Improved approaches for the detection of common epithelial malignancies are urgently needed to reduce the worldwide morbidity and mortality caused by cancer. MicroRNAs (miRNAs) are small ( approximately 22 nt) regulatory RNAs that are frequently dysregulated in cancer and have shown promise as tissue-based markers for cancer classification and prognostication. We show here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity. miRNAs originating from human prostate cancer xenografts enter the circulation, are readily measured in plasma, and can robustly distinguish xenografted mice from controls. This concept extends to cancer in humans, where serum levels of miR-141 (a miRNA expressed in prostate cancer) can distinguish patients with prostate cancer from healthy controls. Our results establish the measurement of tumor-derived miRNAs in serum or plasma as an important approach for the blood-based detection of human cancer."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Circulating microRNAs as stable blood-based markers for cancer detection."],"pmcid":["PMC2492472"],"funding_grant_id":["5 P01 CA085859","P01 CA085859","P30 DK56465","P50 CA083636","P30 DK056465","P50 CA83636","P50 CA097186","P50 CA97186"],"pubmed_authors":["Stirewalt DL","Parkin RK","Wyman SK","Knudsen BS","Pogosova-Agadjanyan EL","Peterson A","Lin DW","Allen A","Tewari M","Urban N","Fritz BR","Kroh EM","Gentleman R","Noteboom J","O'Briant KC","Drescher CW","Martin DB","Nelson PS","Vessella RL","Mitchell PS"],"additional_accession":[]},"is_claimable":false,"name":"Circulating microRNAs as stable blood-based markers for cancer detection.","description":"Improved approaches for the detection of common epithelial malignancies are urgently needed to reduce the worldwide morbidity and mortality caused by cancer. MicroRNAs (miRNAs) are small ( approximately 22 nt) regulatory RNAs that are frequently dysregulated in cancer and have shown promise as tissue-based markers for cancer classification and prognostication. We show here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity. miRNAs originating from human prostate cancer xenografts enter the circulation, are readily measured in plasma, and can robustly distinguish xenografted mice from controls. This concept extends to cancer in humans, where serum levels of miR-141 (a miRNA expressed in prostate cancer) can distinguish patients with prostate cancer from healthy controls. Our results establish the measurement of tumor-derived miRNAs in serum or plasma as an important approach for the blood-based detection of human cancer.","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Jul","modification":"2026-03-16T16:23:01.043Z","creation":"2025-08-30T03:09:41.906Z"},"accession":"S-EPMC2492472","cross_references":{"pubmed":["18663219"],"doi":["10.1073/pnas.0804549105"]}}