{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4"],"submitter":["Busch H"],"pubmed_abstract":["Translation of large-scale data into a coherent model that allows one to simulate, predict and control cellular behavior is far from being resolved. Assuming that long-term cellular behavior is reflected in the gene expression kinetics, we infer a dynamic gene regulatory network from time-series measurements of DNA microarray data of hepatocyte growth factor-induced migration of primary human keratinocytes. Transferring the obtained interactions to the level of signaling pathways, we predict in silico and verify in vitro the necessary and sufficient time-ordered events that control migration. We show that pulse-like activation of the proto-oncogene receptor Met triggers a responsive state, whereas time sequential activation of EGF-R is required to initiate and maintain migration. Context i"],"journal":["Molecular systems biology"],"pagination":["199"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2516358"],"repository":["biostudies-literature"],"pubmed_title":["Gene network dynamics controlling keratinocyte migration."],"pmcid":["PMC2516358"],"pubmed_authors":["Szabowski A","Breuhahn K","Angel P","Eils R","Camacho-Trullio D","Busch H","Rogon Z"],"additional_accession":[]},"is_claimable":false,"name":"Gene network dynamics controlling keratinocyte migration.","description":"Translation of large-scale data into a coherent model that allows one to simulate, predict and control cellular behavior is far from being resolved. Assuming that long-term cellular behavior is reflected in the gene expression kinetics, we infer a dynamic gene regulatory network from time-series measurements of DNA microarray data of hepatocyte growth factor-induced migration of primary human keratinocytes. Transferring the obtained interactions to the level of signaling pathways, we predict in silico and verify in vitro the necessary and sufficient time-ordered events that control migration. We show that pulse-like activation of the proto-oncogene receptor Met triggers a responsive state, whereas time sequential activation of EGF-R is required to initiate and maintain migration. Context i","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008","modification":"2026-05-04T12:05:27.199Z","creation":"2026-04-07T20:26:02.073Z"},"accession":"S-EPMC2516358","cross_references":{"pubmed":["18594517"],"doi":["10.1038/msb.2008.36"]}}