{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["99(5)"],"submitter":["Helms MW"],"pubmed_abstract":["Gains of chromosomes 7p and 8q are associated with poor prognosis among oestrogen receptor-positive (ER+) stage I/II breast cancer. To identify transcriptional changes associated with this breast cancer subtype, we applied suppression subtractive hybridisation method to analyse differentially expressed genes among six breast tumours with and without chromosomal 7p and 8q gains. Identified mRNAs were validated by real-time RT-PCR in tissue samples obtained from 186 patients with stage I/II breast cancer. Advanced statistical methods were applied to identify associations of mRNA expression with distant metastasis-free survival (DMFS). mRNA expression of the key enzyme of cholesterol biosynthesis, squalene epoxidase (SQLE, chromosomal location 8q24.1), was associated with ER+ 7p+/8q+ breast c"],"journal":["British journal of cancer"],"pagination":["774-80"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2528137"],"repository":["biostudies-literature"],"pubmed_title":["Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease."],"pmcid":["PMC2528137"],"pubmed_authors":["Pospisil H","Wang A","Vogt U","Chan SY","Korsching E","Kemming D","Buerger H","Schlotter CM","Brandt BH","Liedtke C","Helms MW"],"additional_accession":[]},"is_claimable":false,"name":"Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease.","description":"Gains of chromosomes 7p and 8q are associated with poor prognosis among oestrogen receptor-positive (ER+) stage I/II breast cancer. To identify transcriptional changes associated with this breast cancer subtype, we applied suppression subtractive hybridisation method to analyse differentially expressed genes among six breast tumours with and without chromosomal 7p and 8q gains. Identified mRNAs were validated by real-time RT-PCR in tissue samples obtained from 186 patients with stage I/II breast cancer. Advanced statistical methods were applied to identify associations of mRNA expression with distant metastasis-free survival (DMFS). mRNA expression of the key enzyme of cholesterol biosynthesis, squalene epoxidase (SQLE, chromosomal location 8q24.1), was associated with ER+ 7p+/8q+ breast c","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Sep","modification":"2026-05-03T14:46:36.964Z","creation":"2026-04-07T19:20:39.479Z"},"accession":"S-EPMC2528137","cross_references":{"pubmed":["18728668"],"doi":["10.1038/sj.bjc.6604556"]}}