{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["De Luca M"],"funding":["NCRR NIH HHS","NIDDK NIH HHS","NHLBI NIH HHS"],"pagination":["52"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2533007"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["<h4>Background</h4>The objective of the present study was to map candidate loci influencing naturally occurring variation in triacylglycerol (TAG) storage using quantitative complementation procedures in Drosophila melanogaster. Based on our results from Drosophila, we performed a human population-based association study to investigate the effect of natural variation in LAMA5 gene on body composition in humans.<h4>Results</h4>We identified four candidate genes that contributed to differences in TAG storage between two strains of D. melanogaster, including Laminin A (LanA), which is a member of the alpha subfamily of laminin chains. We confirmed the effects of this gene using a viable LanA mutant and showed that female flies homozygous for the mutation had significantly lower TAG storage, b"],"journal":["BMC genetics"],"pubmed_title":["Genetic variation in a member of the laminin gene family affects variation in body composition in Drosophila and humans."],"pmcid":["PMC2533007"],"funding_grant_id":["R01 DK049779","R01DK51694","P30DK56336","R01DK49779","R01 HL080812","P30 DK056336","R01HL80812","M01RR00032","M01 RR000032"],"pubmed_authors":["Hunter GR","Fernandez JR","De Luca M","Lok KH","Gower BA","Chambers MM","Casazza K"],"additional_accession":[]},"is_claimable":false,"name":"Genetic variation in a member of the laminin gene family affects variation in body composition in Drosophila and humans.","description":"<h4>Background</h4>The objective of the present study was to map candidate loci influencing naturally occurring variation in triacylglycerol (TAG) storage using quantitative complementation procedures in Drosophila melanogaster. Based on our results from Drosophila, we performed a human population-based association study to investigate the effect of natural variation in LAMA5 gene on body composition in humans.<h4>Results</h4>We identified four candidate genes that contributed to differences in TAG storage between two strains of D. melanogaster, including Laminin A (LanA), which is a member of the alpha subfamily of laminin chains. We confirmed the effects of this gene using a viable LanA mutant and showed that female flies homozygous for the mutation had significantly lower TAG storage, b","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Aug","modification":"2026-04-18T15:16:36.627Z","creation":"2026-04-07T14:41:03.82Z"},"accession":"S-EPMC2533007","cross_references":{"pubmed":["18694491"],"doi":["10.1186/1471-2156-9-52"]}}